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Varim, C., Gokosmanoglu, F., & Oztop, K. E. (2020). Clinical Evaluation on Non-Functional Invasive Hypophysis Adenomas. Sudan Journal of Medical Sciences (SJMS), 15(2), 106–113. https://doi.org/10.18502/sjms.v15i2.5027

https://doi.org/10.18502/sjms.v15i2.5027

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authors

  • Ceyhun Varim

    Ceyhun Varim

  • Feyzi Gokosmanoglu

    Feyzi Gokosmanoglu

    Department of Endocrinology, Medical Park Hospital, Ordu, Turkey
  • Kenan Evren Oztop

    Kenan Evren Oztop

    Department of Internal Medicine, Konak Hospital, Sakarya, Turkey

Published Date

  • Jun 25, 2020

Clinical Evaluation on Non-Functional Invasive Hypophysis Adenomas

Sudan Journal of Medical Sciences (SJMS) / Sudan JMS: Volume 15 (2020), Issue No. 2 / Pages 106–113

Abstract

Background


There are ongoing studies to predetermine non-functional invasive pituitary adenomas which may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in non-functional pituitary adenomas.


Materials and Methods


In this study, we evaluated retrospectively the files of the patients who were diagnosed with thesellar or parasellar tumor in our endocrinology clinic between the years of 2004-2014.The patients were divided into two groups as non-invasive pituitary adenomas and non-functional invasive pituitary adenomas. The immunohistochemical staining characteristics were compared between the two groups.


Results


In this study, we scanned the data of 70 patients who were followed for non-functional sellar or parasellar mass. 47.1% of the patients were female and 52.9% of the patients were male.39 patients had a non-functional pituitary adenoma.The rate of non-functional invasive adenoma was found to be 20.5%. There was a significant relationship between the immunohistochemical positivity of GH, FSH, LH andaggressive behavior of non-functional invasive adenomas. There was no a significant relationship between the immunohistochemicalpositivityof PRL, ACTH, TSH and aggressive behavior of non-functional invasive adenomas.


Conclusion


We found silent GH and gonadotropin adenomas as non-functional aggressive pituitary adenoma. More aggressive treatment and close clinical monitoring should be performed because atypical pituitary adenomas are characterized by invasive growth and aggressive clinical course.

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