The Influence of Hypoxic Hypoxia and Antiorthostatic Hypokinesia on the Activity of Motoneuron Pools in Man

Abstract

The paper presents study results of the possible modulating effects of intermittent normobaric hypoxic hypoxia and antiorthostatic hypokinesia on motoneuron pools activity m. soleus and m. gastrocnemius. The unidirectional conditioning of the monosynaptic spinal H-reflex was revealed under non-specific effects of hypoxia and antiorthostasis. After 19 days of exposure, an increase in the amplitudes of the H- and M- responses, activation thresholds of the action potential of Ia sensory fibers was observed, which led to the induction of a maximal H-response in both muscles at a greater stimulus level. There was also a pronounced decrease in the H-reflex depression, which is apparently associated with a weakening effect of suprasegmental control systems in the cumulative effect of a 19-day intermittent (interval) normobaric hypoxic hypoxia and antiorthostatic hypokinesia.

References
[1] VN Komantsev, VA Zabolotnykh. Methodical bases of clinical electroneuromyography: A guide for physicians. St. Petersburg: Publishing House ”Lan”, 2001. P. 215-216.


[2] Kots Y.M. Organization of voluntary movement: Neurophysiological mechanisms. M.: Nauka, 1975. P. 30-38.


[3] Persons R.S. Spinal mechanisms for controlling muscle contraction. M.: Nauka, 1985. P. 110.4.


[4] Aagaard P., Simonsen E., Andersen J., Magnusson P., Dyhre-Poulsen P. Neural adaptation to resistance training: changes in evoked V-wave and H-reflex responses // J. Appl. Physiol. 2002. Vol. 92, Issue 6. P. 2309-2318.


[5] Badier M, Guillot C, Lagier-Tessonnier F, Jammes Y. EMG changes in respiratory and skeletal muscles during isometric contraction under normoxic, hypoxemic, or ischemic conditions // Muscle Nerve. 1994. Vol. 17. Issue 5. P. 500-508.


[6] Caquelard F., Burnet H., Tagliarini F., Cauchy E., Richalet J.P., Jammes Y. Effects of prolonged hypobaric hypoxia on human skeletal muscle function and electromyographic events // Clin. Sci. (Lond.). 2000. P. 329-337.


[7] Clark B.C., Manini T.M., Bolanowski S.J., Ploutz-Snyder L.L. Adaptations in human neuromuscular function following prolonged unweighting: Neurological properties and motor imagery efficacy // J. Appl. Physiol. 2006. Vol. 101, Issue 3. P. 264-272.


[8] Del Balso C., Cafarelli E. Adaptations in the activation of human skeletal muscle induced by short-term isometric resistance training // J. Appl. Physiol. 2007. Vol. 103, Issue 1. P. 402-411.


[9] Duclay J., Martin A. Evoked H-Reflex and V-Wave responses during maximal isometric, concentric, and eccentric muscle contraction // J. Neurophysiol. 2005. Vol. 94, Issue 5. P. 3555-3562.


[10] Jammesa Y., Zattara-Hartmanna M.C., M. Badiera. Functional consequences of acute and chronic hypoxia on respiratory and skeletal muscles in mammals // Compar. Biochem. and Physiol. Part A: Physiol. 1997. Vol. 118. Issue 1. P. 15-22.


[11] Jensen J.L., Marstrand P.C.D., Nielsen J.B. Motor skill training and strength training are associated with different plastic changes in the central nervous system // J. Appl. Physiol. 2005. Vol. 99, Issue 4. P. 1558-1568.


[12] Willer J.C., Miserocchi G., Gautier H. Hypoxia and monosynaptic reflexes in humans // J. Appl. Physiol. 1987. Vol. 63. Issue 2. P. 639-645.