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Sadat Najib, F., Poordast, T., Rezvan Nia, M., & Hossein Dabbaghmanesh, M. (2020). Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial. International Journal of Reproductive BioMedicine (IJRM), 18(1), 57-64. https://doi.org/10.18502/ijrm.v18i1.6201
https://doi.org/10.18502/ijrm.v18i1.6201
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- Cited by 8 articles
authors
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Fatemeh Sadat Najib
Fatemeh Sadat Najib
Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
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Tahereh Poordast
Tahereh Poordast
Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
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Mina Rezvan Nia
Mina Rezvan Nia
Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
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Mohammad Hossein Dabbaghmanesh
Mohammad Hossein Dabbaghmanesh
Endocrin and Metabolic Research center of Internal Medicine Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Published Date
- Jan 26, 2020
Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial
Abstract
Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).
Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.
Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100μg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.
Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2- hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).
Conclusion: The results of this trial suggest that supplementation with 100μg of selenium does not modulate glucose homeostasis in women with GDM.
Key words: Diabetes, Gestational, Selenium.
References
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[2] Harlev A, Wiznitzer A. New insights on glucose pathophysiology in gestational diabetes and insulin resistance. Curr Diab Rep 2010; 10: 242–247.
[3] Coustan DR. Gestational diabetes mellitus. Clin Chem 2013; 59: 1310–1321.
[4] Chen X, Scholl TO, Leskiw MJ, Donaldson MR, Stein TP. Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy. J Clin Endocrinol Metab 2003; 88: 5963–5968.
[5] Ghaemi SZ, Forouhari S, Dabbaghmanesh MH, Sayadi M, Bakhshayeshkaram M, Vaziri F, et al. A prospective study of selenium concentration and risk of preeclampsia in pregnant Iranian women: a nested case-control study. Biol Trace Elem Res 2013; 152: 174–179.
[6] Hu Y, McIntosh GH, Young GP. Selenium-rich foods: a promising approach to colorectal cancer prevention. Curr Pharm Biotechnol 2012; 13: 165–172.
[7] Kalkan Ucar S, Coker M, Sozmen E, Goksen Simsek D, Darcan S. An association among iron, copper, zinc, and selenium, and antioxidative status in dyslipidemic pediatric patients with glycogen storage disease types IA and III. J Trace Elem Med Biol 2010; 24: 42–45.
[8] Rayman MP. Selenium and human health. Lancet 2012; 379: 1256–1268.
[9] Nawrot TS, Staessen JA, Roels HA, Den Hond E, Thijs L, Fagard RH, et al. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur Heart J 2007; 28: 628–633.
[10] Schnabel R, Lubos E, Messow CM, Sinning CR, Zeller T, Wild PS, et al. Selenium supplementation improves antioxidant capacity in vitro and in vivo in patientswith coronary artery disease: The Selenium Therapy in Coronary Artery disease Patients (SETCAP) Study. Am Heart J 2008; 156: 1201. e1–e11.
[11] Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Sun XD, et al. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J Clin Nutr 2004; 79: 80–85.
[12] Duntas LH. Selenium and inflammation: Underlying antiinflammatory mechanisms. Horm Metab Res 2009; 41: 443–447.
[13] Ezaki O. The insulin like effect of selenate in rat adipocytes. J Biol Chem 1990; 265: 1124–1128.
[14] Stapleton SR. Selenium: an insulin-mimetic. Cell Mol Life Sci 2000; 57: 1874–1879.
[15] Kilinc M, Guven MA, Ezer M, Ertas IE, Coskun A. Evaluation of serum selenium levels in Turkishwomenwith gestational diabetes mellitus, glucose intolerants, and normal controls. Biol Trace Elem Res 2008; 123: 35–40.
[16] Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo Jr J. Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy. Biol Trace Elem Res 2008; 121: 16–22.
[17] Al-Saleh E, Nandakumaran M, Al-Rashdan I, Al-Harmi J, Al-Shammari M. Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. Acta Diabetol 2007; 44: 106–113.
[18] Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Nutrition 2015; 31: 1235–1242.
[19] American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36 (Suppl.): S67–S74.
[20] Institute of medicine national academy of sciences food nutrition board panel on dietary antioxidants and related compounds.dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington DC: National Academy Press; 2000.
[21] Jamilian M, Samimi M, Afshar Ebrahimi F, Aghadavod E, Mohammadbeigi R, Rahimi M, et al. Effects of selenium supplementation on Gene expression levels of inflammatory cytokines and vascular endothelial growth factor in patients with gestational diabetes. Biol Trace Elem Res 2018; 181: 199–206.
[22] Landon MB, Rice MM, Varner MW, Casey BM, Reddy UM, Wapner RJ, et al. Mild gestational diabetes mellitus and long-term child health. Diabetes Care 2015; 38: 445–452.
[23] Retnakaran R, Shah BR. Impact of twin gestation and fetal sex on maternal risk of diabetes during and after pregnancy. Diabetes Care 2016; 39: 110–111.
[24] Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research. Ann Intern Med 2013; 159: 123–129.
[25] Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 2006; 15: 804–810.
[26] Rees K, Hartley L, Day C, Flowers N, Clarke A, Stranges S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013; 1: CD009671.
[27] Aldosary BM, Sutter ME, Schwartz M, Morgan BW. Case series of selenium toxicity from a nutritional supplement. Clin Toxicol (Phila) 2012; 50: 57–64.
[28] Vinceti M, Wei ET, Malagoli C, Bergomi M, Vivoli G. Adverse health effects of selenium in humans. Rev Environ Health 2001; 16: 233–251.
[2] Harlev A, Wiznitzer A. New insights on glucose pathophysiology in gestational diabetes and insulin resistance. Curr Diab Rep 2010; 10: 242–247.
[3] Coustan DR. Gestational diabetes mellitus. Clin Chem 2013; 59: 1310–1321.
[4] Chen X, Scholl TO, Leskiw MJ, Donaldson MR, Stein TP. Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy. J Clin Endocrinol Metab 2003; 88: 5963–5968.
[5] Ghaemi SZ, Forouhari S, Dabbaghmanesh MH, Sayadi M, Bakhshayeshkaram M, Vaziri F, et al. A prospective study of selenium concentration and risk of preeclampsia in pregnant Iranian women: a nested case-control study. Biol Trace Elem Res 2013; 152: 174–179.
[6] Hu Y, McIntosh GH, Young GP. Selenium-rich foods: a promising approach to colorectal cancer prevention. Curr Pharm Biotechnol 2012; 13: 165–172.
[7] Kalkan Ucar S, Coker M, Sozmen E, Goksen Simsek D, Darcan S. An association among iron, copper, zinc, and selenium, and antioxidative status in dyslipidemic pediatric patients with glycogen storage disease types IA and III. J Trace Elem Med Biol 2010; 24: 42–45.
[8] Rayman MP. Selenium and human health. Lancet 2012; 379: 1256–1268.
[9] Nawrot TS, Staessen JA, Roels HA, Den Hond E, Thijs L, Fagard RH, et al. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur Heart J 2007; 28: 628–633.
[10] Schnabel R, Lubos E, Messow CM, Sinning CR, Zeller T, Wild PS, et al. Selenium supplementation improves antioxidant capacity in vitro and in vivo in patientswith coronary artery disease: The Selenium Therapy in Coronary Artery disease Patients (SETCAP) Study. Am Heart J 2008; 156: 1201. e1–e11.
[11] Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Sun XD, et al. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J Clin Nutr 2004; 79: 80–85.
[12] Duntas LH. Selenium and inflammation: Underlying antiinflammatory mechanisms. Horm Metab Res 2009; 41: 443–447.
[13] Ezaki O. The insulin like effect of selenate in rat adipocytes. J Biol Chem 1990; 265: 1124–1128.
[14] Stapleton SR. Selenium: an insulin-mimetic. Cell Mol Life Sci 2000; 57: 1874–1879.
[15] Kilinc M, Guven MA, Ezer M, Ertas IE, Coskun A. Evaluation of serum selenium levels in Turkishwomenwith gestational diabetes mellitus, glucose intolerants, and normal controls. Biol Trace Elem Res 2008; 123: 35–40.
[16] Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo Jr J. Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy. Biol Trace Elem Res 2008; 121: 16–22.
[17] Al-Saleh E, Nandakumaran M, Al-Rashdan I, Al-Harmi J, Al-Shammari M. Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies. Acta Diabetol 2007; 44: 106–113.
[18] Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Nutrition 2015; 31: 1235–1242.
[19] American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36 (Suppl.): S67–S74.
[20] Institute of medicine national academy of sciences food nutrition board panel on dietary antioxidants and related compounds.dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington DC: National Academy Press; 2000.
[21] Jamilian M, Samimi M, Afshar Ebrahimi F, Aghadavod E, Mohammadbeigi R, Rahimi M, et al. Effects of selenium supplementation on Gene expression levels of inflammatory cytokines and vascular endothelial growth factor in patients with gestational diabetes. Biol Trace Elem Res 2018; 181: 199–206.
[22] Landon MB, Rice MM, Varner MW, Casey BM, Reddy UM, Wapner RJ, et al. Mild gestational diabetes mellitus and long-term child health. Diabetes Care 2015; 38: 445–452.
[23] Retnakaran R, Shah BR. Impact of twin gestation and fetal sex on maternal risk of diabetes during and after pregnancy. Diabetes Care 2016; 39: 110–111.
[24] Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research. Ann Intern Med 2013; 159: 123–129.
[25] Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 2006; 15: 804–810.
[26] Rees K, Hartley L, Day C, Flowers N, Clarke A, Stranges S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013; 1: CD009671.
[27] Aldosary BM, Sutter ME, Schwartz M, Morgan BW. Case series of selenium toxicity from a nutritional supplement. Clin Toxicol (Phila) 2012; 50: 57–64.
[28] Vinceti M, Wei ET, Malagoli C, Bergomi M, Vivoli G. Adverse health effects of selenium in humans. Rev Environ Health 2001; 16: 233–251.