@article{Sadat Najib_Poordast_Rezvan Nia_Hossein Dabbaghmanesh_2020, title={Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial}, volume={18}, url={https://knepublishing.com/index.php/ijrm/article/view/6201}, DOI={10.18502/ijrm.v18i1.6201}, abstractNote={<p><strong>Background:</strong> There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).</p> <p><strong>Objective:</strong> This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.</p> <p><strong>Materials and Methods:</strong> A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100μg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.</p> <p><strong>Results:</strong> The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2- hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).</p> <p><strong>Conclusion:</strong> The results of this trial suggest that supplementation with 100μg of selenium does not modulate glucose homeostasis in women with GDM.</p> <p><em><strong>Key words:</strong> Diabetes, Gestational, Selenium.</em></p&gt;}, number={1}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Sadat Najib, Fatemeh and Poordast, Tahereh and Rezvan Nia, Mina and Hossein Dabbaghmanesh, Mohammad}, year={2020}, month={Jan.}, pages={57-64} }