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https://doi.org/10.18502/espoch.v1i6.9653

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  • Iván Enrique Naranjo Logroño

    Iván Enrique Naranjo Logroño

    Departamento de Ginecología. Carrera de Medicina, Facultad de Salud Pública, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador
  • Leslie Gricel Cuzco Macías

    Leslie Gricel Cuzco Macías

    Departamento de Ginecología. Carrera de Medicina, Facultad de Salud Pública, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador
  • Carla Victoria Sandoval Flores

    Carla Victoria Sandoval Flores

    Departamento de Ginecología. Carrera de Medicina, Facultad de Salud Pública, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador
  • Anthony Alfonso Naranjo Coronel

    Anthony Alfonso Naranjo Coronel

    COLPOMED Centro- Hospital del día. Riobamba, Chimborazo, Ecuador

Published Date

  • Sep 9, 2021

Epigenetics in the Transgenerational Transmission of Chronic Diseases in the Context of Poverty with a Perinatal Approach

ESPOCH Congresses: The Ecuadorian Journal of S.T.E.A.M. / Volume 1, Issue 6 / Pages 1619–1625

Abstract

Introduction: Epigenetics is relevant in obstetrics for its action during pregnancy, in embryo-fetal life and even for the events that exist at birth. Objective: To investigate and analyze information about the role that epigeomics plays in the transgenerational transmission of chronic diseases in the context of poverty with a perinatal approach. Methods: Through a non-systematic bibliographic review through the search engines: LILACS, CINAHL, COCHRANE, EBSCO, MEDLINE, SCIELO, SCOPUS and PUBMED. Results: 32 bibliographic publications were found, of which 30 articles containing information related to the topic were included. Discussion: The genome has been compared to the hardware of a computer, while the epigenetic information is compared to the software that controls the operation of the hardware. Furthermore, the factors affecting epigenetic information can be analog as parameters to operate the software. Conclusion: The epigenomics studies the process by which the expression of certain genes occurs, in order to reduce the probability of the appearance of chronic diseases, having a potential effect during pregnancy and neonatal period.


Keywords: epigenomics, transcription, genetic, poverty, chronic disease.


RESUMEN

Introducción: La epigenética tiene relevancia en la obstetricia por su acción durante el embarazo, en la vida embrio-fetal e inclusive, por los sucesos que existen al nacimiento. Objetivo: Investigar y analizar de información acerca del rol que juega la epigenómica en la transmisión transgeneracional de las enfermedades crónicas en el contexto de la pobreza con enfoque perinatal. Métodos: Por medio de una revisión bibliográfica no sistemática a través de los buscadores: LILACS, CINAHL, COCHRANE, EBSCO, MEDLINE, SCIELO, SCOPUS y PUBMED. Resultados: Se encontraron 32 publicaciones bibliográficas, de las cuales se incluyeron 30 artículos que contenían la información relacionada al tema. Discusión: El genoma se lo ha comparado con el hardware de una computadora, mientras que la información epigenética se lo compara con el software que controla el funcionamiento del hardware. Además, los factores que afectan la información epigenética pueden ser analógicos como parámetros para operar el software. Conclusiones: La epigenómica estudia proceso por el cual se da la expresión de determinados genes, con la finalidad de disminuir la probabilidad de la aparición de enfermedades crónicas, teniendo un efecto potencial durante el embarazo y periodo neonatal.


Palabras clave: epigenómica, transcripción genética, pobreza, enfermedad crónica.

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