``Osteogenesis imperfecta'' and ``vitreous osteoporosis'' are genetic diseases in most of their cases, that is, it is sufficient for one of the parents to be a disease carrier in order to have one of their children suffering from it. It is the main protein source in the bone structure leading to this disorder; however, the genetic factor is the most common and accounts for about 80 to 85% of the causes of osteogenesis imperfecta. The congenital bone disorder is associated with a defect in the connective tissue, which leads to the inability to build or form bones. It leads to easy bone fractures, and the cause of these fractures is often unclear.
Keywords: rulings, jurisprudence, syndrome, epigenetics, bone, Lobstein, jurisprudence, Islamic.