Toxic Effect of Lead on the Red Marrow Cells of Birds
Abstract
The purpose of this study was to determine the main patterns of the toxic effect of lead on the red marrow cells of birds in the first three days after exposure. The electro-microscopic study revealed that the toxic effect of lead nitrate on bone marrow cells begins even at a slight MAL excess after 1 day of intoxication. Hematopoietic and stromal marrow cells mainly show the signs of dystrophic changes, which increase as the term after exposure to lead nitrate increases. In the cytoplasm of many cells, heterogeneous lipid inclusions are formed, which are likely the lipid products of cell membrane destruction. In lead intoxication of chickens, the structure of the cell nuclei in the bone marrow is changed, and the morphological characteristics reveal a decrease in the transcription of ribosomal RNA genes and the preparation of many cells for apoptosis.
Keywords: lead toxic effect, birds, marrow cells
References
[1] Kosian D., Bykov A., Kvan O., Gavrish I., Lebedev S. (2019). Morphological and Functional Changes in the Small Intestine and Liver of Laboratory Animals After Feeding With Cavitation-Treated Feed. 44th FEBS Congress, which took place in Krakow, Poland from 6th to 11th July 2019, Open Bio, vol. 9, p. 282.
[2] Vishnyakov. A. I. (2019). Influence of Diets with the Various Nutrient Provision on the Mineral Metabolism in Broiler Chicken’s Organism. Proc. of Conference on Innovations in Agricultural and Rural development 18–19 April 2019, Kurgan, Russian Federation. IOP Publishing, IOP Conference Series: Earth and Environmental Science, vol. 341.
[3] Vishnyakov, A. I., Udavliev, D. I., Timofeev, D. N. and Satyukova, L. P. (2019). Peculiarities of the Bone-Marrow Hemopoiesis, Peripheral Blood, and the Elemental Status of the Red Bone Marrow of Poultry Resulted from Copper Introduction. Proc. of Conference on Innovations in Agricultural and Rural development 18–19 April 2019, Kurgan, Russian Federation. IOP Publishing, IOP Conference Series: Earth and Environmental Science, vol. 341.
[4] Kireeva, Y. V., Shubina, O. S. Liver Morphological Alterations in Response to Lead Poisoning (2006). Fundamental Studies, vol. 1, p. 97.
[5] Sheida, E., Sipailova, O., Miroshnikov, S., Sizova, E., Lebedev, S, Rusakova, E., Notova, S. (2017). The Effect of Iron Nanoparticles on Performance of Cognitive Tasks in Rats. Environmental Science and Pollution Research, vol. 24, issue 9, pp. 8700-8710.
[6] Skalnyi, A. V., Salnikova, E. V., Burtseva, T. I., Skalnaya, M. G., Tinkov, A. A. (2019). Zinc, Copper, Cadmium, and Lead Levels in Cattle Tissues in Relation to Different Metal Levels in Ground Water and Soil. Environmental Science and Pollution Research, vol. 26, issue 1, pp. 559-569.
[7] Sorkina, N. S., Kuzmina, L. P., Artyomova, L. B., Besrukavnikova, L. M. (2019). Labor Medicine and Industrial Ecology, vol. 59, issue 12, pp. 983-988.
[8] Schiptsova, N. V., Larionov, G. A., Terentieva, M. G. (2019). Accumulation Dynamics of Chemical Xenobiotics in the Animal Organism and Their Extraction Mechanism. Journal of Mari State University Agricultural Sciences Economic Sciences, vol. 51, issue 17, pp. 66-72.
[9] Kvan, O., Gavrish, I., Lebedev, S., Korotkova, A., Miroshnikova, E., Bykov, A., Serdaeva, V., Davydova, N. (2018). Effect of Probiotics on the Basis of Bacillus Subtilis and Bifidobacteriumlongum on the Biochemical Parameters of the Animal Organism. Environmental Science and Pollution Research, vol. 25, issue 3, рр. 2175-2183.
[10] Lebedev, S. V., Gavrish, I. A., Gubajdullina, I. Z., Shabunin, S. V. (2019). Effects Caused by Different Doses of Dietary Chromium Nanoparticles Fed to Broiler Chickens. Agricultural Biology, vol. 54, issue 4, pp. 820-831.
[11] Rusakova, Е. A., Lebedev, S. V., Gavrish, I. A., Kvan, O. V., Sheida, Е. V. (2019). Changes in the Haemostatic System and the Activity of Digestive Enzymes of Rats When Exposed to NPs CuZn. Bioscience research, vol. 16, issue 3, pp. 2563-2576.
[12] Lebedev, S., Gavrish, I., Gubajdullina, I., Kvan, O. (2019). The Effect of Nanoparticles on Mineral Metabolism in the Body of Laboratory Animals. 19th International Multidisciplinary Scientific GeoConference SGEM 2019, 30 June - 6 July