Toxic Effect of Lead on the Red Marrow Cells of Birds
The purpose of this study was to determine the main patterns of the toxic effect of lead on the red marrow cells of birds in the first three days after exposure. The electro-microscopic study revealed that the toxic effect of lead nitrate on bone marrow cells begins even at a slight MAL excess after 1 day of intoxication. Hematopoietic and stromal marrow cells mainly show the signs of dystrophic changes, which increase as the term after exposure to lead nitrate increases. In the cytoplasm of many cells, heterogeneous lipid inclusions are formed, which are likely the lipid products of cell membrane destruction. In lead intoxication of chickens, the structure of the cell nuclei in the bone marrow is changed, and the morphological characteristics reveal a decrease in the transcription of ribosomal RNA genes and the preparation of many cells for apoptosis.
Keywords: lead toxic effect, birds, marrow cells
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