Typhoid Pediatric Inpatient Clinical Symptoms, Laboratory and Antibiotic Treatment


Clinical features of typhoid fever vary from mild to severe. Laboratory examination for typhoid fever in Indonesia still uses the Widal test as a diagnostic tool. In 1992, isolates of S.typhi showed resistance to fluoroquinolones, with the first case reported in the United Kingdom. Similar cases were reported from several other countries, including India. This study aimed to describe the clinical symptoms, laboratory and antibiotics used for children with typhoid hospitalized at Hospital ‘X’ in West Java from January to March 2017. This research was a descriptive retrospective, using a cross-sectional design with a total sample of 127 respondents. The study was conducted from January to March 2018. Patients suffering from typhoid were hospitalized at Hospital ‘X’, West Java, were 37% aged between 5-9 years old with 51.18% males and those whose length of stay was for 3 days was 29.13%. Widal Titer O positive examination was 13.91% and positive H Titer was 45.21%, positive tubex 93.75%, 26.77% leukopenia, 48.81% with Hb value <11.5, the patient had a fever of 99.21%, 85.03% was given ceftriaxone. Clinical symptoms that are often experienced by children with typhoid typhoid is fever and the antibiotics that are often given are ceftriaxone.

Keywords: typhoid fever, widal titer, resistance

[1] WHO. World Health Organization. Immunization, Vaccines and Biologicals; 2018.

[2] Paputungan W. Pharmacon. 2016;5:2.

[3] WHO. Guidelines for the Management of Typhoid Fever. 2018

[4] Kool J. Guidelines for the diagnosis, management, and prevention of typhoid fever. Minnistry of Health Fiji Islands. WHO. 2010.

[5] Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia 2010. Jakarta: Kemenkes; 2011.

[6] Erviani AE. Biogenesis. Jurnal Ilmiah Biologi. 2013;1(1):51–60.

[7] Mirza S, Kariuki S, Mamun KZ, Beeching NJ, Hart CA. Analysis of plasmid and chromosomal DNA of multidrug-resistant Salmonella enterica serovar typhi from Asia. J Clin Microbiol. 2000 Apr;38(4):1449–52.

[8] Rampling NH. Sari Pediatr. 2013;14:271–6.

[9] Mikhail IA, Hyams KC, Podgore JK, Haberberger RL, Boghdadi AM, Mansour NS, et al. Microbiologic and clinical study of acute diarrhea in children in Aswan, Egypt. Scand J Infect Dis. 1989;21(1):59–65.

[10] Zaki SA, Karande S. Multidrug-resistant typhoid fever: a review. J Infect Dev Ctries. 2011 May;5(5):324–37.

[11] Adiputra IK, Somia IK. E-Jurnal Med. Udayana. 2017;6:98–102.

[12] Md G, Jemadi R. Karakteristik penderita demam tifoid yang dirawat inap di Rumah Sakit Santa Elisabeth Medan Tahun 2016. Univ Sumatera Utara; 2010.

[13] Devaranavadagi RA, Srinivasa S, Int J. A study on clinical profile of typhoid fever in children. Int J Contemp Pediatrics. 2017;4(3):1067–73.

[14] Anggraini AB, Opitasari C, Sari QA. Heal. Sci. J. Indones. 2014;5:40–3.

[15] S. S and S. H. I. Pilihan terapi empiris demam tifoid pada anak : kloramfenikol atau seftriakson? Sari Pediatri. 2010;11:434-9.

[16] Chatterjee A. Pediatric Salmonella Infection Treatment & Management. Medscape. 2016. https://emedicine.medscape.com/article/968672-treatment