Exploring Anticancer Potential in Bajakah Tampala by In Silico Virtual Screening
Incidences of cancer have increased sharply throughout the world. The process of finding a targeted cancer drug takes a long time and a lot of money. One method that can help overcome this is computational methods, such as virtual screening. It can be an important alternative in early-stage drug discovery. The aim of this study is to explore and analyze the potential protein targets of Bajakah tampala (Spatholobulus littoralis) as an anticancer chemotherapy. This is a bioinformatics study that uses the in silico method through the pathway analysis method with PubChem software, Swiss Target prediction, String and Cytoscope. The results showed that many phytochemicals present in Spatholobulus littoralis Hask are predicted to be anticancer.
Keywords: Anticancer, Bajakah tampala, In silico, Spatholobulus littoralis
 International Agency for Research on Cancer. Latest world cancer statistics Global cancer burden rises to 14.1 million new cases in 2012: Marked increase in breast cancers must be addressed World Health Organization. 2013
 Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019 Apr;144(8):1941–53.
 Kilic U, Sahin K, Tuzcu M, Basak N, Orhan C, Elibol-Can B, et al. Enhancement of Cisplatin sensitivity in human cervical cancer: epigallocatechin-3-gallate. Front Nutr. 2015 Jan;1:28.
 Wang F, Liu M, Li X, Tang H. MiR-214 reduces cell survival and enhances cisplatininduced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells. FEBS Lett. 2013 Mar;587(5):488–95.
 Ninkaew S, Chantaranothai P. Tropical. Nat Hist. 2014;14(2):87–99.
 Saputera MM, Ayuchecaria N. Jurnal Ilmiah Ibnu Sina. 2018;3:318–27.
 Lavecchia A, Di Giovanni C. Virtual screening strategies in drug discovery: a critical review. Curr Med Chem. 2013;20(23):2839–60.
 Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V. SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res. 2014 Jul;42(Web Server issue W1):32-8.
 Dunkel M, Günther S, Ahmed J, Wittig B, Preissner R. SuperPred: drug classification and target prediction. Nucleic Acids Res. 2008 Jul;36(Web Server issue suppl_2):55- 9.
 Li W, Liu J, Guan R, Chen J, Yang D, Zhao Z, et al. Chemical characterization of procyanidins from Spatholobus suberectus and their antioxidative and anticancer activities. J Funct Foods. 2015;12:468–77.
 Lee MH, Lin YP, Hsu FL, Zhan GR, Yen KY. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. Phytochemistry. 2006 Jun;67(12):1262–70.]
 Chahar MK, Sharma N, Dobhal MP, Joshi YC. Flavonoids: A versatile source of anticancer drugs. Pharmacogn Rev. 2011 Jan;5(9):1–12.
 Bribi N. Pharmacological activity of alkaloids: a review. Asian Journal Botany. 2018;1(2):1–6.
 Heleno SA, Martins A, Queiroz MJ, Ferreira IC. Bioactivity of phenolic acids: metabolites versus parent compounds: a review. Food Chem. 2015 Apr;173:501– 13.
 Sytar O, Hemmerich I, Zivcak M, Rauh C, Brestic M. Comparative analysis of bioactive phenolic compounds composition from 26 medicinal plants. Saudi J Biol Sci. 2018 May;25(4):631–41.
 Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, et al. Chemopreventive potential of green tea catechins in hepatocellular carcinoma. Int J Mol Sci. 2015 Mar;16(3):6124–39.
 Sur S, Pal D, Mandal S, Roy A, Panda CK. Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways. J Nutr Biochem. 2016 Jan;27:32–42.