The Clinicopathology Profile of Adenocarcinoma Colorectal


Colorectal adenocarcinoma is the second deadliest cancer in the world. It starts in the large intestine and rectum. At Hasan Sadikin Hospital Bandung, the incidence of this disease was 224 cases in 2015, 187 cases in 2016, 212 cases in 2017. The mortality rate and prognosis of individuals suffering from Colorectal Adenocarcinoma were related to their clinicopathological profile. This paper is a cross-sectional study in which the Clinicopathological data comes from the medical records of patients at Hasan Sadikin Hospital between 2015 and 2017. Wald’s statistics was used to analyze the results of the data in the 95% confidence range/interval. There were 149 samples, and the number of men and women were similar. The mean age was 57. The study discovered that the proportion of carcinomas in the left colon (71.23%, 95% CI 63.31- 78.04%) were much higher than in the right colon (28.77%, 95%CI 21.95- 36.69). The anatomical pathological features of NOS dominated the sample (95.3%, 95% CI 90.42- 97.76%) far more than non-NOS/mucinous. The proportion of grading well differentiation was slightly higher in the moderate-poor differentiation group. T3, N0, and Mx were the most common staging in this study. Lymphovascular invasion was the most common invasion (55.7%, 95% CI 47.58- 63.53%). The results are in line with a Chinese study that stated that the Adenocarcinoma NOS variant is the most common variant and has a better prognosis. However, the location of the tumors in Indonesia s were predominantly on the left colon, while tumors found in the Chinese were predominantly on the right colon. The primary staging of patients in this study were T3, while in the Chinese study, it was primarily T4. Lymphovascular invasions were more common in patients in this study compared to that in China. This shows that there are differences in pathogenesis, molecular genetics and severity.

Keywords: adenocarcinoma colorectal, clinicopathology

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