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Gulnara Batyrova
Gulnara Batyrova
Department of Clinical Laboratory and Visual Diagnostics, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Published Date
- Mar 14, 2024
The Role of Cobalt in Human Health: A Brief Overview
Abstract
Cobalt is a crucial trace element for the human body. It serves as an essential
component of vitamin B12 and plays a pivotal role in the synthesis of amino acids and
select proteins within nerve cells, as well as in the synthesis of neurotransmitters vital
for the proper functioning of the body. Both excess and deficiency of cobalt can have
detrimental effects on the human body. Notwithstanding the paramount significance
of cobalt as a trace element, comprehensive studies are necessary to evaluate its role
in physiological processes.
Keywords: cobalt, human health, trace element, vitamin B12, physiological processes
References
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[2] Czarnek K, Terpiłowska S, Siwicki AK Selected aspects of the action of cobalt ions in the human body. Cent Eur J Immunol. 2015;40(2);236-42. doi: 10.5114/ceji.2015.52837.
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[5] Kubasov RV, Gorbachev AL, Kubasova ED The role of bioelements in increasing the volume of the thyroid gland in children living in the coastal region. Human Ecology. 2007;6: 9-14. (In Russian).
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[10] Maynar M, Llerena F, Grijota FJ, Pérez-Quintero M, Bartolomé I., Alves J, Robles MC, Muñoz D. Serum concentration of cobalt, molybdenum and zinc in aerobic, anaerobic and aerobic-anaerobic sportsmen. J Int Soc Sports Nutr. 2018;15(1):28. doi: 10.1186/s12970-018-0233-z.
[11] Fort M, Grimalt JO, Casas M, Sunyer J. Interdependence between urinary cobalt concentrations and hemoglobin levels in pregnant women. Environ Res. 2015;136;148-54. doi: 10.1016/j.envres.2014.10.013. Epub 2014 Nov 20. PMID: 25460631.
[12] Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans: A review of the potential sources and systemic health effects. Toxicology.2017;15(387);43-56. doi: 10.1016/j.tox.2017.05.015.
[13] Paustenbach DJ, Tvermoes BE, Unice KM, Finley BL, Kerger BD A review of the health hazards posed by cobalt. Crit Rev Toxicol. 2013;43(4):316-62. doi: 10.3109/10408444.2013.779633.
[14] Zhang H, Xu Z, Zhang J, Wei D, Liu K, Hu W, Wang J. Disordered serum essential element levels are associated with increased risk of kidney tumors. Environ Sci Pollut Res Int.
[15] 2022;29(21):31675-31685. doi: 10.1007/s11356-021-18201-y.
[16] Skalny AV, Zaitseva IP, Gluhcheva YG, Skalny AA, Achkasov EE, Skalnaya MG, Tinkov AA. Cobalt in athletes: Hypoxia and doping: New crossroads. J Appl Biomed. 2018; https://doi.org/10.32725/jab.2018.003.
[17] Detkov VYu, Skalny AV, Karganov MYu, Cherepov AB, Medvedeva YuS, Glazov MYu, Isankina LN Cobalt deficiency in children with low functional reserve. Technologies of Living Systems. 2013; 10(7): 022-028 (In Russ.).
[18] Simonsen LO, Harbak H, Bennekou P Cobalt metabolism and toxicology: A brief update. Science of the Total Environment. 2012; 432: 210-215.
[19] Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans: A review of the potential sources and systemic health effects. Toxicology. 2017; 387: 43-56.
[20] Mitchell C J, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. American Journal of Physiology -Cell Physiology. 2013.
[21] Kambe T, Yamaguchi-Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cellular and molecular life sciences CMLS. 2004; 61(1): 49-68.
[22] Ortega R, Bresson C, Fraysse A, Sandre C, Devès G, Gombert C, Moretto P. Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis. Toxicologyletters. 2009; 188(1): 26-32.
[23] Glukhcheva Y, Tinkov AA, Aisuvakova OP, Grabeklis AR, Pavlova E, Petrova E, Zaitseva Yu V, Vladov I, Skalny AV. The influence of perinatal exposure to cobalt on the metabolism of iron, copper, manganese, and zinc in the body of immature ICR mice. Questions of biological, medical, and pharmaceutical chemistry. 2019;22(3):3−8.
[24] Skalny AV, Gluhcheva Y, Ajsuvakova OP, Pavlova E, Petrova E, Rashev P, Vladov I., Shakieva RA, Aschner M, Tinkov AA. Perinatal and early-life cobalt exposure impairs essential metal metabolism in immature ICR mice. Food Chem Toxicol. 2021;149:111973. doi: 10.1016/j.fct.2021.111973.
[25] Junqué E, Grimalt JO, Fernández-Somoano A, Tardón A. Urinary cobalt and ferritin in four-years-old children. Environ Res. 2020;183:109147. doi: 10.1016/j.envres.2020.109147.
[26] Andersson L, Hedbrant A, Bryngelsson IL, Persson A, Johansson A, Ericsson A, Vihlborg P, Sjögren B, Särndahl E, Stockfelt L, Westberg H. Respiratory health and inflammatory markers-exposure to cobalt in the Swedish Hard Metal Industry. J Occup Environ Med. 2020;62(10)820-829. doi: 10.1097/JOM.0000000000001952.
[27] Scarselli A, Di Marzio D, Iavicoli S. Assessment of exposure to cobalt and its compounds in Italian industrial settings. Med Lav. 2020;111(1):22-31. doi: 10.23749/mdl.v111i1.8869
[2] Czarnek K, Terpiłowska S, Siwicki AK Selected aspects of the action of cobalt ions in the human body. Cent Eur J Immunol. 2015;40(2);236-42. doi: 10.5114/ceji.2015.52837.
[3] Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM The essential metals for humans: A brief overview. J Inorg Biochem. 2019;195:120-129. doi: 10.1016/j.jinorgbio.2019.03.013.
[4] Miftakhov S F, Abdulin I F, Svyatova NV Assessment of the morphofunctional status of children with health problems depending on the cobalt content in the body. Problems and prospects of physical education, sports training and adaptive physical culture. 2018;904-908. (In Russian).
[5] Kubasov RV, Gorbachev AL, Kubasova ED The role of bioelements in increasing the volume of the thyroid gland in children living in the coastal region. Human Ecology. 2007;6: 9-14. (In Russian).
[6] Lison D, Van den Brule S, Van Maele-Fabry G. Cobalt and its compounds: Update on genotoxic and carcinogenic activities. Critical Reviews in Toxicology. 2018;48(7):522- 539. doi: 10.1080/10408444.2018.1491023
[7] Wang H, Li F, Xue J, Li Y, Li J. Association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in a US population: A cross-sectional study. Medicine. 2022;101(2):e28568. https://doi.org/10.1097/MD.0000000000028568
[8] Zhou JY, Hou HT, Wang SF, Yang Q, He GW Plasma concentrations of trace elements selenium and cobalt during and after coronary artery bypass grafting surgery. Acta Med Okayama. 2022;76(1)33-39. doi: 10.18926/AMO/63206.
[9] Okamoto S, Eltis LD The biological occurrence and trafficking of cobalt. Metallomics. 2011;3(10) 963-70. doi: 10.1039/c1mt00056j.
[10] Maynar M, Llerena F, Grijota FJ, Pérez-Quintero M, Bartolomé I., Alves J, Robles MC, Muñoz D. Serum concentration of cobalt, molybdenum and zinc in aerobic, anaerobic and aerobic-anaerobic sportsmen. J Int Soc Sports Nutr. 2018;15(1):28. doi: 10.1186/s12970-018-0233-z.
[11] Fort M, Grimalt JO, Casas M, Sunyer J. Interdependence between urinary cobalt concentrations and hemoglobin levels in pregnant women. Environ Res. 2015;136;148-54. doi: 10.1016/j.envres.2014.10.013. Epub 2014 Nov 20. PMID: 25460631.
[12] Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans: A review of the potential sources and systemic health effects. Toxicology.2017;15(387);43-56. doi: 10.1016/j.tox.2017.05.015.
[13] Paustenbach DJ, Tvermoes BE, Unice KM, Finley BL, Kerger BD A review of the health hazards posed by cobalt. Crit Rev Toxicol. 2013;43(4):316-62. doi: 10.3109/10408444.2013.779633.
[14] Zhang H, Xu Z, Zhang J, Wei D, Liu K, Hu W, Wang J. Disordered serum essential element levels are associated with increased risk of kidney tumors. Environ Sci Pollut Res Int.
[15] 2022;29(21):31675-31685. doi: 10.1007/s11356-021-18201-y.
[16] Skalny AV, Zaitseva IP, Gluhcheva YG, Skalny AA, Achkasov EE, Skalnaya MG, Tinkov AA. Cobalt in athletes: Hypoxia and doping: New crossroads. J Appl Biomed. 2018; https://doi.org/10.32725/jab.2018.003.
[17] Detkov VYu, Skalny AV, Karganov MYu, Cherepov AB, Medvedeva YuS, Glazov MYu, Isankina LN Cobalt deficiency in children with low functional reserve. Technologies of Living Systems. 2013; 10(7): 022-028 (In Russ.).
[18] Simonsen LO, Harbak H, Bennekou P Cobalt metabolism and toxicology: A brief update. Science of the Total Environment. 2012; 432: 210-215.
[19] Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans: A review of the potential sources and systemic health effects. Toxicology. 2017; 387: 43-56.
[20] Mitchell C J, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. American Journal of Physiology -Cell Physiology. 2013.
[21] Kambe T, Yamaguchi-Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cellular and molecular life sciences CMLS. 2004; 61(1): 49-68.
[22] Ortega R, Bresson C, Fraysse A, Sandre C, Devès G, Gombert C, Moretto P. Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis. Toxicologyletters. 2009; 188(1): 26-32.
[23] Glukhcheva Y, Tinkov AA, Aisuvakova OP, Grabeklis AR, Pavlova E, Petrova E, Zaitseva Yu V, Vladov I, Skalny AV. The influence of perinatal exposure to cobalt on the metabolism of iron, copper, manganese, and zinc in the body of immature ICR mice. Questions of biological, medical, and pharmaceutical chemistry. 2019;22(3):3−8.
[24] Skalny AV, Gluhcheva Y, Ajsuvakova OP, Pavlova E, Petrova E, Rashev P, Vladov I., Shakieva RA, Aschner M, Tinkov AA. Perinatal and early-life cobalt exposure impairs essential metal metabolism in immature ICR mice. Food Chem Toxicol. 2021;149:111973. doi: 10.1016/j.fct.2021.111973.
[25] Junqué E, Grimalt JO, Fernández-Somoano A, Tardón A. Urinary cobalt and ferritin in four-years-old children. Environ Res. 2020;183:109147. doi: 10.1016/j.envres.2020.109147.
[26] Andersson L, Hedbrant A, Bryngelsson IL, Persson A, Johansson A, Ericsson A, Vihlborg P, Sjögren B, Särndahl E, Stockfelt L, Westberg H. Respiratory health and inflammatory markers-exposure to cobalt in the Swedish Hard Metal Industry. J Occup Environ Med. 2020;62(10)820-829. doi: 10.1097/JOM.0000000000001952.
[27] Scarselli A, Di Marzio D, Iavicoli S. Assessment of exposure to cobalt and its compounds in Italian industrial settings. Med Lav. 2020;111(1):22-31. doi: 10.23749/mdl.v111i1.8869