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Mellati, A., & Akhtari, J. (2019). Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications. Research in Molecular Medicine (RMM), 6(4), 1–14. https://doi.org/10.18502/rmm.v6i4.4799
https://doi.org/10.18502/rmm.v6i4.4799
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Amir Mellati
Amir Mellati
School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, 48471-91971, Iran; Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, 48471-91971, Iran; Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, 48471- 91971, Iran
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Javad Akhtari
Javad Akhtari
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, 48471-91971, Iran; Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, 48471- 91971, Iran
Published Date
- Jul 14, 2019
Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications
Abstract
Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneous mixing with cells and therapeutic agents, minimally invasive administration, and perfect defect filling. In this review, we discuss various mechanisms which facilitate injectability of hydrogels, including in situ gelling liquids, injectable gels, and injectable particles. Then, we explore the biomedical applications of injectable hydrogels, including tissue engineering, therapeutic agent delivery, and medical devices.
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[3] Dimatteo R, Darling NJ, Segura T. In situ forming injectable hydrogels for drug delivery and wound repair. Adv Drug Deliv Rev. 2018;127:167-84.
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[7] Klouda L. Thermoresponsive hydrogels in biomedical applications: A seven-year update. Eur J Pharm Biophar. 2015;97:338-49.
[8] Jeong B, Kim SW, Bae YH. Thermosensitive sol–gel reversible hydrogels. Adv Drug Deliv Rev. 2012;64:154-62.
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[10] Chenite A, Chaput C, Wang D, Combes C, Buschmann M, Hoemann C, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials. 2000;21(21):2155-61.
[11] Joly-Duhamel C, Hellio D, Djabourov M. All gelatin networks: 1. Biodiversity and physical chemistry. Langmuir. 2002;18(19):7208-17.
[12] Lanzalaco S, Armelin E. Poly (N-isopropylacrylamide) and copolymers: a review on recent progresses in biomedical applications. Gels. 2017;3(4):36.
[13] Mellati A, Kiamahalleh MV, Dai S, Bi J, Jin B, Zhang H. Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide). Mater Sci Eng C. 2016;59:509-13.
[14] Alexandridis P, Hatton TA. Poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf A. 1995;96(1-2):1-46.
[15] Jung Y-s, Park W, Park H, Lee D-K, Na K. Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery. Carbohydr Polym. 2017;156:403-8.
[16] Oh SH, Kang JG, Lee JH. Co-micellized Pluronic mixture with thermo-sensitivity and residence stability as an injectable tissue adhesion barrier hydrogel. J Biomed Mater Res B. 2018;106(1):172-82.
[17] Choi WI, Hwang Y, Sahu A, Min K, Sung D, Tae G, et al. An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation. Biomater Sci. 2018;6(10):2627-38.
[18] Alexander A, Khan J, Saraf S, Saraf S. Poly (ethylene glycol)–poly (lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications. J Control Release. 2013;172(3):715-29.
[19] Gong C, Shi S, Wu L, Gou M, Yin Q, Guo Q, et al. Biodegradable in situ gelforming controlled drug delivery system based on thermosensitive PCL–PEG–PCL hydrogel. Part 2: Sol–gel–sol transition and drug delivery behavior. Acta Biomater. 2009;5(9):3358-70.
[20] Zhang W, Xu W, Ning C, Li M, Zhao G, Jiang W, et al. Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia. Biomaterials. 2018;181:378-91.
[21] Saghebasl S, Davaran S, Rahbarghazi R, Montaseri A, Salehi R, Ramazani A. Synthesis and in vitro evaluation of thermosensitive hydrogel scaffolds based on (PNIPAAm-PCL-PEG-PCL-PNIPAAm)/Gelatin and (PCL-PEG-PCL)/Gelatin for use in cartilage tissue engineering. J Biomater Sci Polym Ed. 2018;29(10):1185-206.
[22] Mellati A, Dai S, Bi J, Jin B, Zhang H. A biodegradable thermosensitive hydrogel with tuneable properties for mimicking three-dimensional microenvironments of stem cells. RSC Adv. 2014;4(109):63951-61.
[23] Mellati A, Fan CM, Tamayol A, Annabi N, Dai S, Bi J, et al. Microengineered 3D cellladen thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering. Biotech Bioeng. 2017;114(1):217-31.
[24] Gupta P, Vermani K, Garg S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today. 2002;7(10):569-79.
[25] Nguyen QV, Huynh DP, Park JH, Lee DS. Injectable polymeric hydrogels for the delivery of therapeutic agents: A review. Euro Polym J. 2015;72:602-19.
[26] Mathew AP, Uthaman S, Cho K-H, Cho C-S, Park I-K. Injectable hydrogels for delivering biotherapeutic molecules. Int J Biol Macromol. 2018;110:17-29.
[27] Xu X-D, Zhang X-Z, Cheng S-X, Zhuo R-X, Kennedy JF. A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity. Carbohydr Polym. 2007;68(3):416-23.
[28] Kim HK, Shim WS, Kim SE, Lee K-H, Kang E, Kim J-H, et al. Injectable in situ– forming pH/thermo-sensitive hydrogel for bone tissue engineering. Tissue Eng A. 2008;15(4):923-33.
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