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Bakhti, M., Haghshenas, M., Valadan, R., & Rudsari, M. R. (2018). Prevalence of HBV/HCV Infections in HIV-Positive Patients in Northern Iran. Research in Molecular Medicine (RMM), 5(4), 61–68. https://doi.org/10.18502/rmm.v5i4.3066
https://doi.org/10.18502/rmm.v5i4.3066
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- Cited by 4 articles
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Mehrnaz Bakhti
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-
Mohammadreza Haghshenas
No author data available.
-
Reza Valadan
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Mehdi Rabie Rudsari
No author data available.
Published Date
- Oct 10, 2018
Prevalence of HBV/HCV Infections in HIV-Positive Patients in Northern Iran
Abstract
Introduction: Human immunodeficiency virus (HIV) infection increases the risk of infection with other pathogens, including hepatitis B virus (HBV) and hepatitis C virus (HCV). A crucial aspect of HIV prevention and treatment programs is knowledge of the prevalence of co-infection of HIV and HBV and/or HCV. This study sought to determine HBV and HCV co-infection in HIV-positive patients in northern Iran.
Materials and Methods: Blood samples were collected from 83 HIV-positive patients whose infection was previously confirmed by real-time polymerase chain reaction in the HIV center in the North of Iran. A structured questionnaire was used to obtain socio-demographic data from participants. Samples were screened for hepatitis B surface antigen and anti-HCV antibody. All non-reactive samples were recorded as negative.
Results: The 83 patients comprised 50 (60%) males and 33 (40%) females. Twenty eight (33%) and 15 (18%) subjects were positive for HCV antibody and hepatitis B surface antigen, respectively. Seven (8%) of subjects were co-infected with all three viruses.
Conclusion: Seroprevalence of HCV and HIV co-infection was high and was strongly related to mutual acquisition.
References
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[24] Bollepalli S, Mathieson K, Bay C, Hillier A, Post J, Van Thiel DH, et al. Prevalence of risk factors for hepatitis C virus in HIV-infected and HIV/hepatitis C virus-coinfected patients. Sex Transm Dis. 2007;34(6):367-70.
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[26] Rockstroh JK, Mocroft A, Soriano V, Tural C, Losso MH, Horban A, et al. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005;192(6):992-1002.
[27] Alavi SM, Etemadi A. HIV/HBV, HIV/HCV and HIV/HTLV-1 co infection among injecting drug user patients
hospitalized at the infectious disease ward of a training hospital in Iran. Pak J Med Sci. 2007;23(4):510.
[28] Otegbayo JA, Taiwo BO, Akingbola TS, Odaibo GN, Adedapo KS, Penugonda S, et al. Prevalence of hepatitis B and C seropositivity in a Nigerian cohort of HIV-infected patients. Ann Hepatol. 2008;7(2):152-6.
[29] Mahajan A, Tandon V, Verma S, Singh J, Sharma M. Prevalence of tuberculosis, hepatitis B, hepatitis C and syphilis co-infections among HIV/AIDS patients. Indian J Med Microbiol. 2008;26(2):196.
[30] Puglia M, Stasi C, Da Frè M, Voller F. Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany. Braz J Infect Dis. 2016;20(4):330-4.
[31] Muriuki BM, Gicheru MM, Wachira D, Nyamache AK, Khamadi SA. Prevalence of hepatitis B and C viral co-infections among HIV-1 infected individuals in Nairobi, Kenya. BMC Res Notes. 2013;6(1):363.
[32] Wolff F, Fuchs S, Barcellos N, Falavigna M, Cohen M, Brandão A, et al. Risk factors for hepatitis C virus infection in individuals infected with the HIV. Dig Liver Dis. 2008;40(6):460-7.
[33] Alter MJ. Prevention of spread of hepatitis C. Hepatology. 2002;36(5B).
[2] Koziel MJ, Peters MG. Viral hepatitis in HIV infection. N Engl J Med. 2007;356(14):1445-54.
[3] Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61(1):S58-S68.
[4] Noubiap JJN, Aka PV, Nanfack AJ, Agyingi LA, Ngai JN, Nyambi PN. Hepatitis B and C Co-Infections in Some HIV-Positive Populations in Cameroon, West Central Africa: Analysis of Samples Collected Over More Than a Decade. PloS one. 2015;10(9):e0137375.
[5] Weber R, Ruppik M, Rickenbach M, Spörri A, Furrer H, Battegay M, et al. Decreasing mortality and
changing patterns of causes of death in the Swiss HIV Cohort Study. HIV Med. 2013;14(4):195-207.
[6] Jansen K, Thamm M, Bock C-T, Scheufele R, Kücherer C, Muenstermann D, et al. High prevalence and high incidence of coinfection with hepatitis B, hepatitis C, and syphilis and low rate of effective vaccination against hepatitis B in HIV-positive men who have sex with men with known date of HIV seroconversion in Germany. PLoS One. 2015;10(11):e0142515.
[7] Limketkai BN, Mehta SH, Sutcliffe CG, Higgins YM, Torbenson MS, Brinkley SC, et al. Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCV. Jama. 2012;308(4):370-8.
[8] Ashraf H, Alam NH, Rothermundt C, Brooks A, Bardhan P, Hossain L, et al. Prevalence and risk factors of hepatitis B and C virus infections in an impoverished urban community in Dhaka, Bangladesh. BMC Infect Dis. 2010;10(1):1.
[9] Chen J-J, Yu C-B, Du W-B, Li L-J. Prevalence of hepatitis B and C in HIV-infected patients: a meta-analysis. Hepatobiliary & Pancreatic Dis Int. 2011;10(2):122-7.
[10] Mansour-Ghanaei F, Fallah M, Jafarshad R, Joukar F, Pourtahmasbi A, Bahari-Moghaddam A. Seroprevalence of hepatitis B and C among residents of Guilan Nursing Home. Hepat Mon. 2007;7(3):139-1141.
[11] Sy T, Jamal MM. Epidemiology of hepatitis C virus (HCV) infection.Int J Med Sci. 2006;3(2):41.
[12] Daw MA, Shabash A, El-Bouzedi A, Dau AA. Seroprevalence of HBV, HCV & HIV co-infection and risk factors analysis in Tripoli-Libya. PloS one. 2014;9(6):e98793.
[13] Haghshenas MR, Arabi M, Mousavi T. Hepatitis B genotypes in iran. Mater Sociomed. 2014;26(2):129.
[14] Makhloogh A, Mahdavi M, Haghshenas M, Ghasemian R, Jamshidi M. Hepatitis C prevalence in hemodialysis patients in Mazandaran, Iran: A survey by polymerase chain reaction and serological methods. Res J Biol Sci. 2008;3(4):265-8.
[15] Rafiei A, Darzyani AM, Taheri S, Haghshenas M, Hosseinian A, Makhlough A. Genetic diversity of HCV among various high risk populations (IDAs, thalassemia, hemophilia, HD patients) in Iran. Asian Pac J Trop Biomed. 2013;6(7):556-60.
[16] Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol. 2006;44:S6-S9.
[17] Kuehlkamp VM, Schuelter-Trevisol F. Prevalence of human immunodeficiency virus/hepatitis C virus co-infection in Brazil and associated factors: a review. Braz J Infect Dis: an official publication of the Brazilian Society of Infectious Diseases. 2013 Jul-Aug;17(4):455-63. PubMed PMID: 23680064. Epub 2013/05/18. eng.
[18] Zahedi MJ, Moghaddam SD, Abasi MH, Parnian M, Shokoohi M. Hepatitis B, C virus co-infection and behavioral risks in HIV-positive patients in southern Iran. J Pak Med Assoc. 2014;64(2):134-7.
[19] Mohammadi M, Talei G, Sheikhian A, Ebrahimzade F, Pournia Y, Ghasemi E, et al. Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patients. Virol J. 2009;6(1):202.
[20] Taherkhani R, Farshadpour F. Epidemiology of hepatitis C virus in Iran. WJG. 2015;21(38):10790.
[21] Ranjbar R, Davari A, Izadi M, Jonaidi N, Alavian SM. HIV/HBV co-infections: epidemiology, natural history, and treatment: a review article. Iran Red Crescent Med J. 2011;2011(12, Dec):855-62.
[22] Feuth T, Arends JE, Fransen JH, Nanlohy NM, van Erpecum KJ, Siersema PD, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PloS one. 2013;8(3):e59302.
[23] Wolff FH, Fuchs SC, Barcellos NN, De Alencastro PR, Ikeda MLR, Brandão AB, et al. Co-infection by hepatitis C virus in HIV-infected patients in southern Brazil: genotype distribution and clinical correlates. PloS one.
2010;5(5):e10494.
[24] Bollepalli S, Mathieson K, Bay C, Hillier A, Post J, Van Thiel DH, et al. Prevalence of risk factors for hepatitis C virus in HIV-infected and HIV/hepatitis C virus-coinfected patients. Sex Transm Dis. 2007;34(6):367-70.
[25] Sherman KE, Rouster SD, Chung RT, Rajicic N. Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clin Infect Dis. 2002;34(6):831-7.
[26] Rockstroh JK, Mocroft A, Soriano V, Tural C, Losso MH, Horban A, et al. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005;192(6):992-1002.
[27] Alavi SM, Etemadi A. HIV/HBV, HIV/HCV and HIV/HTLV-1 co infection among injecting drug user patients
hospitalized at the infectious disease ward of a training hospital in Iran. Pak J Med Sci. 2007;23(4):510.
[28] Otegbayo JA, Taiwo BO, Akingbola TS, Odaibo GN, Adedapo KS, Penugonda S, et al. Prevalence of hepatitis B and C seropositivity in a Nigerian cohort of HIV-infected patients. Ann Hepatol. 2008;7(2):152-6.
[29] Mahajan A, Tandon V, Verma S, Singh J, Sharma M. Prevalence of tuberculosis, hepatitis B, hepatitis C and syphilis co-infections among HIV/AIDS patients. Indian J Med Microbiol. 2008;26(2):196.
[30] Puglia M, Stasi C, Da Frè M, Voller F. Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany. Braz J Infect Dis. 2016;20(4):330-4.
[31] Muriuki BM, Gicheru MM, Wachira D, Nyamache AK, Khamadi SA. Prevalence of hepatitis B and C viral co-infections among HIV-1 infected individuals in Nairobi, Kenya. BMC Res Notes. 2013;6(1):363.
[32] Wolff F, Fuchs S, Barcellos N, Falavigna M, Cohen M, Brandão A, et al. Risk factors for hepatitis C virus infection in individuals infected with the HIV. Dig Liver Dis. 2008;40(6):460-7.
[33] Alter MJ. Prevention of spread of hepatitis C. Hepatology. 2002;36(5B).