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Singh, V., Tamar, N., Lone, Z., Das, E., Sahu, R., & Majumdar, S. (2021). Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study. International Journal of Reproductive BioMedicine (IJRM), 19(11), 979–986. https://doi.org/10.18502/ijrm.v19i11.9913

https://doi.org/10.18502/ijrm.v19i11.9913

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authors

  • Vinita Singh

    Vinita Singh

    Obstetrics and Gynecology Department, Aiims, Raipur, India.
  • Neelam Tamar

    Neelam Tamar

    Obstetrics and Gynecology Department, Aiims, Raipur, India.
  • Zamir Lone

    Zamir Lone

    Obstetrics and Gynecology Department, Aiims, Raipur, India.
  • Esha Das

    Esha Das

    Obstetrics and Gynecology Department, Aiims, Raipur, India.
  • Rajshree Sahu

    Rajshree Sahu

    Obstetrics and Gynecology Department, Aiims, Raipur, India.
  • Sagarika Majumdar

    Sagarika Majumdar

    Obstetrics and Gynecology Department, Aiims, Raipur, India.

Published Date

  • Dec 13, 2021

Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 19, Issue No. 11 / Pages 979–986

Abstract

Background: Research examining the role of vitamin D deficiency and the development of menstrual disorders in women is of widespread interest. Studies have been published showing that supplementation with high-dose vitamin D can lead to the restoration of the menstrual cycle. We lack adequate information regarding the effect of vitamin D levels on the physiology of menstruation and further on fertility in women of reproductive age due to the contradictory results reported by studies.


Objective: To study the association of 25-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity.


Materials and Methods: In this cross-sectional study, serum vitamin D levels of 166 women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = 83) between April-June 2019 were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = 83).


Results: A decreased level of vitamin D was associated with a 13.3 times odds of an irregular cycle (OR (95% CI): 13.30 (5.79-30.60), p < 0.001). 25-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < 0.001) in mean vitamin D levels among the females with irregular cycles vs. regular cycles.


Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed.


Key words: Menstrual disturbances, Ovulation, Reproductive period, Vitamin D deficiency, Dietary supplements, Polycystic ovarian syndrome.

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