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Eftekhar, M., Mohammadi, B., Tabibnejad, N., & Hossein Razi, M. (2021). Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series. International Journal of Reproductive BioMedicine (IJRM), 19(6), 569–574. https://doi.org/10.18502/ijrm.v19i6.9378

https://doi.org/10.18502/ijrm.v19i6.9378

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authors

  • Maryam Eftekhar

    Maryam Eftekhar

    Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Banafsheh Mohammadi

    Banafsheh Mohammadi

    Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    https://orcid.org/0000-0002-9087-9295
  • Nasim Tabibnejad

    Nasim Tabibnejad

    Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mohammad Hossein Razi

    Mohammad Hossein Razi

    Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Published Date

  • Jul 27, 2021

Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 19, Issue No. 6 / Pages 569–574

Abstract

Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation.


Case: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles ≤ 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy.


Conclusion: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes.


Key words: Arrested stimulation cycle, Early oocyte triggering, In vitro maturation, Clinical outcome.

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