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Yavangi, M., Varmaghani, N., Pirdehghan, A., Varmaghani, M., & Faryadras, M. (2021). Comparison of pregnancy outcome in intrauterine insemination-candidate women with and without endometrial scratch injury: An RCT. International Journal of Reproductive BioMedicine (IJRM), 19(5), 457–464. https://doi.org/10.18502/ijrm.v19i5.9255

https://doi.org/10.18502/ijrm.v19i5.9255

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authors

  • Mahnaz Yavangi

    Mahnaz Yavangi

    Endometrium and Endometriosis Research Center, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
  • Nesa Varmaghani

    Nesa Varmaghani

    Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Azar Pirdehghan

    Azar Pirdehghan

    Department of Community and Preventive Medicine, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
  • Maryam Varmaghani

    Maryam Varmaghani

    Department of Radiology Medicine, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
  • Mohammad Faryadras

    Mohammad Faryadras

    Department of Epidemiology and Biostatical, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
    https://orcid.org/0000-0002-4490-6897

Published Date

  • Jun 23, 2021

Comparison of pregnancy outcome in intrauterine insemination-candidate women with and without endometrial scratch injury: An RCT

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 19, Issue No. 5 / Pages 457–464

Abstract

Background: Endometrial scratch injury is considered controversial in increasing the success rate of assisted reproductive technology.


Objective: To compare the pregnancy outcomes in women undergoing intrauterine insemination with and without an endometrial scratch.


Materials and Methods: In this randomized clinical trial, 150 women referred to the Fatemieh Hospital, Hamadan, Iran who were candidates for IUI between December 2017 and December 2018 were randomly assigned into two groups (n = 75/each) with or without an endometrial scratch (as case and control groups, respectively). Women in both groups were in proper and identical protocol for IUI. Chemical and clinical pregnancies, abortion, and live birth rate, also pregnancy complications were compared between the groups.


Results: Chemical and clinical pregnancy rates were higher in the case than the control group (p = 0.25, p = 0.54, respectively). In the case group, the abortion and multiple gestation rates were 14.3% and 4.3%, respectively, while it was 5% in the control group (p = 0.60, p = 0.54 respectively). The endometrium thickness on day 21 was higher in the case group than the control (p = 0.01).


Conclusion: Endometrial scratching in intrauterine insemination women is not associated with an increase in both clinical and clinical pregnancy rates, however, studies with a larger sample size are recommended to evaluate this intervention.


Key words: Pregnancy infertility, Women, Endometrial injury, Pregnancy, Intrauterine insemination.

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