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Aslfalah, H., Jamilian, M., Ansarihadipour, H., Abdollahi, M., & Khosrowbeygi, A. (2020). Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study. International Journal of Reproductive BioMedicine (IJRM), 18(12), 1029–1038. https://doi.org/10.18502/ijrm.v18i12.8024
https://doi.org/10.18502/ijrm.v18i12.8024
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authors
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Hadise Aslfalah
Hadise Aslfalah
Students Research Committee, Arak University of Medical Sciences, Arak, Iran
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Mehri Jamilian
Mehri Jamilian
Department of Gynecology and Obstetrics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran
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Hadi Ansarihadipour
Hadi Ansarihadipour
Department of Biochemistry and Genetics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran
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Mahdi Abdollahi
Mahdi Abdollahi
Decorative and Hygienic Products, Control Laboratory of Food, Beverage, Food and Drug Administration, Arak University of Medical Sciences, Arak, Iran
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Ali Khosrowbeygi
Ali Khosrowbeygi
Department of Biochemistry and Genetics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran
Published Date
- Dec 21, 2020
Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study
Abstract
Background: Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases.
Objective: To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM. Materials and Methods: Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value < 0.05 was considered as statistically significant.
Results: The values of TyG index (p < 0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Conclusion: Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM.
Key words: Lipoic acid, Gestational diabetes, Lipids, Triglycerides, Cholesterol.
References
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[7] Akbari M, Ostadmohammadi V, Lankarani KB, Tabrizi R, Kolahdooz F, Khatibi SR, et al. The effects of alphalipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Metabolism 2018; 87: 56–69.
[8] Di Tucci Ch, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, et al. Alpha lipoic acid in obstetrics and gynecology. Gynecol Endocrinol 2018; 34: 729–733.
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[10] Contreras-Duarte S, Carvajal L, Garchitorena MJ, Subiabre M, Fuenzalida B, Cantin C, et al. Gestational diabetes mellitus treatment schemes modify maternal plasma cholesterol levels dependent to women´ s weight: Possible impact on feto-placental vascular function. Nutrients 2020; 12: 506–527.
[11] Jasper R, Skelding K. Cardiovascular disease risk unmasked by pregnancy complications. Eur J Intern Med 2018; 57: 1–6.
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[13] Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 1972; 18: 499–502.
[14] Niroumand Sh, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G, et al. Atherogenic index of plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran 2015; 29: 240–248.
[15] Pazhohan A, Rezaee Moradali M, Pazhohan N. Association of first-trimester maternal lipid profiles and triglyceride-glucose index with the risk of gestational diabetes mellitus and large for gestational age newborn. J Matern Fetal Neonatal Med 2017; 32: 1167–1175.
[16] Gasevic D, Frohlich J, Mancini GJ, Lear SA. Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study. Lipids Health Dis 2014; 13: 159–168.
[17] Pfalzgraf A, Frigg M, Steinhart H. Alpha.-tocopherol contents and lipid oxidation in pork muscle and adipose tissue during storage. J Agric Food Chem 1995; 43: 1339–1342.
[18] Siangproh W, Rattanarat P, Chailapakul O. Reversephase liquid chromatographic determination of α- lipoic acid in dietary supplements using a borondoped diamond electrode. J Chromatogr A 2010; 1217: 7699–7705.
[19] De Cicco S, Immediata V, Romualdi D, Policola C, Tropea A, Di Florio C, et al. Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Gynecol Endocrinol 2017; 33: 698–701.
[20] Noori N, Tabibi H, Hosseinpanah F, Hedayati M, Nafar M. Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. Int J Vitam Nutr Res 2013; 83: 77–85.
[21] Li Y, Ma QG, Zhao LH, Wei H, Duan GX, Zhang JY, et al. Effects of lipoic acid on immune function, the antioxidant defense system, and inflammationrelated genes expression of broiler chickens fed aflatoxin contaminated diets. Int J Mol Sci 2014; 15: 5649–5662.
[22] Bao XH, Xu J, Chen Y, Yang CL, Ye ShD. Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics. Aging Clin Exp Res 2014; 26: 483–489.
[23] Chang JW, Lee EK, Kim TH, Min WK, Chun S, Lee KU, et al. Effects of α-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. Am J Nephrol 2007; 27: 70–74.
[24] Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alphalipoic acid: A randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr 2012; 21: 12–21.
[25] Di Tomo P, Di Silvestre S, Cordone VGP, Giardinelli A, Faricelli B, Pipino C, et al. Centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. Nutr Metab Cardiovasc Dis 2015; 25: 659–666.
[26] Jin JL, Sun D, Cao YX, Guo YL, Wu NQ, Zhu ChG, et al. Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study. Ann Med 2018; 50: 576–586.
[27] Wu TT, Gao Y, Zheng YY, Ma YT, Xie X. Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids Health Dis 2018; 17: 197–203.
[28] Gasevic D, Frohlich J, Mancini GBJ, Lear SA. The association between triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in a multiethnic primary prevention cohort. Metabolism 2012; 61: 583–589.
[29] dos Santos-Weiss ICR, Réa RR, Fadel-Picheth CMT, Rego FGM, Pedrosa Fde O, Gillery P, et al. The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy. Clin Chim Acta 2013; 418: 1–4.
[2] Lappas M, Hiden U, Desoye G, Froehlich J, Hauguelde Mouzon S, Jawerbaum A. The role of oxidative stress in the pathophysiology of gestational diabetes mellitus. Antioxid Redox Signal 2011; 15: 3061–3100.
[3] Ghate J, Choudhari AR, Ghugare B, Ramji S. Antioxidant role of Vitamin C in normal pregnancy. Biomed Res 2011; 22: 49–51.
[4] Monastra G, De Grazia S, Cilaker Micili S, Goker A, Unfer V. Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage. Expert Opin Drug Deliv 2016; 13: 1695– 1708.
[5] Derosa G, D’Angelo A, Romano D, Maffioli P. A clinical trial about a food supplement 6containing α-lipoic acid on oxidative stress markers in type 2 diabetic patients. Int J Mol Sci 2016; 17: 1802–1809.
[6] Zhang Y, Han P, Wu N, He B, Lu Y, Li Sh, et al. Amelioration of lipid abnormalities by α−Lipoic acid through antioxidative and anti−Inflammatory effects. Obesity 2011; 19: 1647–1653.
[7] Akbari M, Ostadmohammadi V, Lankarani KB, Tabrizi R, Kolahdooz F, Khatibi SR, et al. The effects of alphalipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Metabolism 2018; 87: 56–69.
[8] Di Tucci Ch, Di Feliciantonio M, Vena F, Capone C, Schiavi MC, Pietrangeli D, et al. Alpha lipoic acid in obstetrics and gynecology. Gynecol Endocrinol 2018; 34: 729–733.
[9] Di Fulvio P, Pandolfi A, Formoso G, Di Silvestre S, Di Tomo P, Giardinelli A, et al. Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes. Nutr Metab Cardiovasc Dis 2014; 24: 1337–1345.
[10] Contreras-Duarte S, Carvajal L, Garchitorena MJ, Subiabre M, Fuenzalida B, Cantin C, et al. Gestational diabetes mellitus treatment schemes modify maternal plasma cholesterol levels dependent to women´ s weight: Possible impact on feto-placental vascular function. Nutrients 2020; 12: 506–527.
[11] Jasper R, Skelding K. Cardiovascular disease risk unmasked by pregnancy complications. Eur J Intern Med 2018; 57: 1–6.
[12] American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37 (Suppl.): S81–S90.
[13] Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 1972; 18: 499–502.
[14] Niroumand Sh, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G, et al. Atherogenic index of plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran 2015; 29: 240–248.
[15] Pazhohan A, Rezaee Moradali M, Pazhohan N. Association of first-trimester maternal lipid profiles and triglyceride-glucose index with the risk of gestational diabetes mellitus and large for gestational age newborn. J Matern Fetal Neonatal Med 2017; 32: 1167–1175.
[16] Gasevic D, Frohlich J, Mancini GJ, Lear SA. Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study. Lipids Health Dis 2014; 13: 159–168.
[17] Pfalzgraf A, Frigg M, Steinhart H. Alpha.-tocopherol contents and lipid oxidation in pork muscle and adipose tissue during storage. J Agric Food Chem 1995; 43: 1339–1342.
[18] Siangproh W, Rattanarat P, Chailapakul O. Reversephase liquid chromatographic determination of α- lipoic acid in dietary supplements using a borondoped diamond electrode. J Chromatogr A 2010; 1217: 7699–7705.
[19] De Cicco S, Immediata V, Romualdi D, Policola C, Tropea A, Di Florio C, et al. Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Gynecol Endocrinol 2017; 33: 698–701.
[20] Noori N, Tabibi H, Hosseinpanah F, Hedayati M, Nafar M. Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. Int J Vitam Nutr Res 2013; 83: 77–85.
[21] Li Y, Ma QG, Zhao LH, Wei H, Duan GX, Zhang JY, et al. Effects of lipoic acid on immune function, the antioxidant defense system, and inflammationrelated genes expression of broiler chickens fed aflatoxin contaminated diets. Int J Mol Sci 2014; 15: 5649–5662.
[22] Bao XH, Xu J, Chen Y, Yang CL, Ye ShD. Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics. Aging Clin Exp Res 2014; 26: 483–489.
[23] Chang JW, Lee EK, Kim TH, Min WK, Chun S, Lee KU, et al. Effects of α-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. Am J Nephrol 2007; 27: 70–74.
[24] Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alphalipoic acid: A randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr 2012; 21: 12–21.
[25] Di Tomo P, Di Silvestre S, Cordone VGP, Giardinelli A, Faricelli B, Pipino C, et al. Centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. Nutr Metab Cardiovasc Dis 2015; 25: 659–666.
[26] Jin JL, Sun D, Cao YX, Guo YL, Wu NQ, Zhu ChG, et al. Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study. Ann Med 2018; 50: 576–586.
[27] Wu TT, Gao Y, Zheng YY, Ma YT, Xie X. Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids Health Dis 2018; 17: 197–203.
[28] Gasevic D, Frohlich J, Mancini GBJ, Lear SA. The association between triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in a multiethnic primary prevention cohort. Metabolism 2012; 61: 583–589.
[29] dos Santos-Weiss ICR, Réa RR, Fadel-Picheth CMT, Rego FGM, Pedrosa Fde O, Gillery P, et al. The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy. Clin Chim Acta 2013; 418: 1–4.