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Hajar Sharami, S., Abbasi Ranjbar, Z., Alizadeh, F., & Kazemnejad, E. (2019). The relationship of hyperlipidemia with maternal and neonatal outcomes in pregnancy: A cross-sectional study. International Journal of Reproductive BioMedicine (IJRM), 17(10). https://doi.org/10.18502/ijrm.v17i10.5294

https://doi.org/10.18502/ijrm.v17i10.5294

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  • Cited by 8 articles

authors

  • Seyedeh Hajar Sharami

    Seyedeh Hajar Sharami

    Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Zahra Abbasi Ranjbar

    Zahra Abbasi Ranjbar

    Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Fatemeh Alizadeh

    Fatemeh Alizadeh

    Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Ehsan Kazemnejad

    Ehsan Kazemnejad

    Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran

Published Date

  • Oct 1, 2019

The relationship of hyperlipidemia with maternal and neonatal outcomes in pregnancy: A cross-sectional study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 17, Issue No. 10 /

Abstract

Background: Concentrations of plasma lipids levels during pregnancy clearly increases. According to some studies, dyslipidemia is effective in the incidence of preeclampsia and insulin resistance.


Objective: This study aimed to examine the relationship between hyperlipidemia and maternal and neonatal outcomes in pregnant women.


Materials and Methods: This is a cross-sectional study which was conducted on two groups of pregnant women with hyperlipidemia and normal ones to assess maternal and neonatal outcomes. Maternal data including gestational age, mother’s age, body mass index, and maternal weight gain during pregnancy, gestational diabetes mellitus, preeclampsia, cholestasis, and delivery method. Also, birth weight and Apgar score were gathered as the neonatal outcomes.


Results: The results showed that the prevalence of abnormal lipid parameters increased with increasing gestational age. In pregnant women with dyslipidemia in combination with increased triglyceride, cholesterol and Low-density lipoprotein, and decreased High-density lipoprotein, the incidence rates of gestational diabetes (p < 0.001), preeclampsia (p < 0.001), cholestasis (p = 0.041), fetal growth retardation (p < 0.001), and macrosomia (p < 0.001) were statistically higher.


Conclusion: Dyslipidemia was associated with some adverse effects of pregnancy and harmful fetal outcomes. Therefore, it seems that adding laboratory assessment of lipid profiles before and during pregnancy can be effective in early diagnosis of dyslipidemia.


Key words: Dyslipidemias, Gestational diabetes, Preeclampsia, Fetal macrosomia.

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