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Can Ibano, M., Yasar Sanhal, C., Ozgu-Erdinc, S., & Yucel, A. (2019). Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study. International Journal of Reproductive BioMedicine (IJRM), 17(7), 487–492. https://doi.org/10.18502/ijrm.v17i7.4860

https://doi.org/10.18502/ijrm.v17i7.4860

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authors

  • Mujde Can Ibano

    Mujde Can Ibano

    University of Health Sciences, Dr. Zekai Tahir Burak Women’s Health Care, Education and Research Hospital, Ankara, Turkey
  • Cem Yasar Sanhal

    Cem Yasar Sanhal

    University of Health Sciences, Dr. Zekai Tahir Burak Women’s Health Care, Education and Research Hospital, Ankara, Turkey
  • Seval Ozgu-Erdinc

    Seval Ozgu-Erdinc

    University of Health Sciences, Dr. Zekai Tahir Burak Women’s Health Care, Education and Research Hospital, Ankara, Turkey
  • Aykan Yucel

    Aykan Yucel

    University of Health Sciences, Dr. Zekai Tahir Burak Women’s Health Care, Education and Research Hospital, Ankara, Turkey

Published Date

  • Jul 25, 2019

Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 17, Issue No. 7 / Pages 487–492

Abstract

Background: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes.


Objective: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR).


Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis.


Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 ± 3.0 ng/ml vs 25.9 ± 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p < 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79- 85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%.


Conclusion: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.

References
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[2] American College of Obstetricians and Gynecologists. ACOG Practice bulletin no. 134: fetal growth restriction.
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