Molar cesarean scar ectopic pregnancy: Report of 2 cases with review of literature

Abstract

Background: The occurrence of hydatidiform mole at the cesarean scar site is a rare problem. Few cases have been reported, thus there is not enough information for accurate diagnosis and management of this event.


Case Presentation: Herein, we present 2 cases of an invasive hydatidiform mole embedded in cesarean scar tissue, one presented with occasional hypogastric pain and nausea and another with spotting both with a history of cesarean section. Transvaginal ultrasonography and a considerably high titer of beta-human chorionic gonadotropin blood test suggested the existence of molar pregnancy on the cesarean scar, which was confirmed through histological assessment. In the first case, evacuation of molar pregnancy followed by scar resection at the cesarean scar site led to successful fertility preservation management.


Conclusion: The presence of abdominal pain and unexplained bleeding in a pregnant woman without gestational sac in ultrasonography, strongly suggests ectopic pregnancy. The process of diagnosis should be followed by definitive diagnostic evaluation, including beta-human chorionic gonadotropin titer measurement, ultrasonographic assessment (2 and 3-dimensional), magnetic resonance imaging, diagnostic laparoscopy, and finally biopsy of the lesion.


Key words: Cesarean scar pregnancy, Ectopic pregnancy, Hydatidiform mole, Molar pregnancy.

References
1] Ling Ch, Zhao J, Qi X. Partial molar pregnancy in the cesarean scar: A case report and literature review. Medicine 2018; 97: 26–27.

[2] Zhou L-Y, Zhu X-D, Jiang J, Jiang T-A. Uterine mass after caesarean section: A report of two cases. BMC Pregnancy Childbirth 2020; 20: 508–512.

[3] Yamada Y, Ohira S, Yamazaki T, Shiozawa T. Ectopic molar pregnancy: Diagnostic efficacy of magnetic resonance imaging and review of the literature. Case Rep Obstet Gynecol 2016; 6: 761–767.

[4] Darling A, Albright BB, Strickland KC, Davidson BA. Molar pregnancy: Epidemiology, diagnosis, management, surveillance. Curr Obstet Gynecol Rep 2022; 11: 133–141.

[5] Al-Bataineh R, Rawashdeh Sh, Lataifeh LN, Alzghoul SM, Al Sharie AH, Obeidat R, et al. Cesarean scar ectopic partial molar pregnancy: A case report and a review of literature. Case Rep Womens Health 2023; 39: e00555.

[6] Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F, et al. Outcome of cesarean scar pregnancy managed expectantly: Systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018; 51: 169–175.

[7] Antoine C, Young BK. Cesarean section one hundred years 1920–2020: The good, the bad and the ugly. J Perinat Med 2020; 49: 5–16.

[8] Biswas R, Saxena P, Gupta U, Choudhary N, Chawla R. Persistent trophoblastic disease at cesarean scar. Kathmandu Univ Med J 2016; 56: 376–379.

[9] El Miski F, Touimi Benjelloun A, Bouab M, Lamrissi A, Fichtali K, Bouhya S. Spontaneous uterine rupture during the first trimester of a partial molar pregnancy in a scar uterus: A rare case report. Int J Surg Case Rep 2021; 85: 106229.

[10] Jin F-Sh, Ding D-Ch, Wu G-J, Hwang K-Sh. Molar pregnancy in a cesarean section scar of uterus. J Med Sci 2011; 31: 173–176.

[11] Wu Ch-F, Hsu Ch-Y, Chen Ch-P. Ectopic molar pregnancy in a cesarean scar. Taiwanese J Obstet Gynecol 2006; 45: 343–345.

[12] Potdar N, Navti OB, McParland P, Khare M, Elson J. Diagnosis and management of ectopic molar caesarean scar pregnancy. Ultrasound Obstet Gynecol 2010; 36 (Suppl.): 231.

[13] Vimercati A, de Gennaro AC, Resta L, Cormio G, Cicinelli E. Sonographic and power doppler evaluation of an invasive mole located in a cesarean scar pregnancy. J Ultrasound Med 2016; 35: 1608–1612.

[14] Polat I, Yücel B, Davutoglu S, Erdem B, Gedikbasi A. Persistent trophoblastic disease at caesarean scar and its successful treatment with multiple dose systemic methotrexate after suction curettage. J Obstet Gynaecol 2017; 37: 392–394.

[15] Dagdeviren EG, Dur R, Fadiloglu E, Demirdag E, Ozturk C, Altay M. Molar pregnancy in cesarean section scar: A case report. Turk J Obstet Gynecol 2017; 14: 249–251.

[16] Liu GL, He SC, Shan WJ, Chen HY. Repetitive hydatidiform mole in the cesarean scar: A case report and literature review. Clin Exp Obstet Gynecol 2020; 4: 607–610.

[17] Jiang H-R, Shi W-W, Liang X, Zhang H, Tan Y. Hydatidiform mole in a scar on the uterus: A case report. World J Clin Cases 2020; 26: 1547–1553.

[18] Cain A, Breen MT, Holtz M, Williams-Brown MY. Roboticassisted laparoscopic hysterectomy for management of cesarean scar ectopic concerning for a molar pregnancy. J Minim Invasive Gynecol 2022; 29: S37-S86.

[19] Kriplani I, Srivastava V, Bhardwaj K, Jai N, Kriplani A. Laparoscopic management of partial molar caesarean scar ectopic pregnancy. J Minim Invasive Gynecol 2022; 29: 1221–1223.

[20] Hfaiedh I, Jaafar W, Mallouli F, Ben Mbarek C, Chiba Y, Khalifa N, et al. A molar pregnancy as a cesarean scar pregnancy: About the ninth case and literature review. Am J Surg Case Rep 2023; 4: 0114–0116.