https://doi.org/10.18502/ijrm.v22i1.15235
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authors
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Mohammad Golshan Tafti
Mohammad Golshan Tafti
Department of Pediatrics, Ali-ebn-Abitaleb School of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran.
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Marjan Jafari
Marjan Jafari
Department of Neonatology, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
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Seyed Reza Mirjalili
Seyed Reza Mirjalili
Department of Neonatology, Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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Razieh Fallah
Razieh Fallah
Department of Pediatrics, Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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Farimah Shamsi
Farimah Shamsi
Center for Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Published Date
- Feb 18, 2024
Prediction of underweight, short stature, and microcephaly based on brain diffusion-weighted imaging sequence in neonates with stage.2 of hypoxic-ischemic encephalopathy: A follow-up study
Abstract
Background: Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently.
Objective: This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage 2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence.
Materials and Methods: Medical records and growth parameters of 35 neonates with gestational age > 34 wk who were admitted with stage 2 of HIE in Neonatal Intensive Care Unit of Shahid Sadoughi hospital, Yazd, Iran from March 2021-March 2022, and its relationship with neonatal brain DWI sequence finding was evaluated.
Results: 15 girls and 20 boys with a mean birth weight of 2880.3 ± 221.8 gr were evaluated. Conventional magnetic resonance imaging and DWI were found to be abnormal in 6 (17.1%) and 18 neonates (51.4%). The most abnormal finding of DWI was high signal in basal ganglia/thalamus in 9 neonates (25.7%). Abnormal DWI is more frequent in neonates with seizures and low birth weight. Hospital stay days were more prolonged in neonates with abnormal DWI. Microcephaly at 12 months was more frequent in children with abnormal DWI.
Conclusion: In survivors of moderate neonatal HIE, abnormal brain DWI sequence might predict inappropriate head growth, and need close medical and nutritional interventions for growth improvement.
Key words: Hypoxic ischemia encephalopathy, Magnetic resonance imaging, Diffusion weighted imaging, Microcephaly, Underweight.
References
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