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Vahidi, S., Abedinzadeh, M., Rahavian, A., Mirjalili, A., Sadeghi, A., Karami, H., & Abouei, S. (2023). Does Clomiphene citrate administration increase the success rate of microdissection testicular sperm extraction in non-obstructive azoospermic men? A cross-sectional study. International Journal of Reproductive BioMedicine (IJRM), 21(11), 943–948. https://doi.org/10.18502/ijrm.v21i11.14658

https://doi.org/10.18502/ijrm.v21i11.14658

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authors

  • Serajoddin Vahidi

    Serajoddin Vahidi

    Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Mehdi Abedinzadeh

    Mehdi Abedinzadeh

    Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Amirhossein Rahavian

    Amirhossein Rahavian

    Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Alimohammad Mirjalili

    Alimohammad Mirjalili

    Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Ali Sadeghi

    Ali Sadeghi

    Department of Surgical Technology, Faculty of Paramedical, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Hormoz Karami

    Hormoz Karami

    Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Saeid Abouei

    Saeid Abouei

    Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Published Date

  • Dec 14, 2023

Does Clomiphene citrate administration increase the success rate of microdissection testicular sperm extraction in non-obstructive azoospermic men? A cross-sectional study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 21, Issue No. 11 / Pages 943–948

Abstract

Background: Clomiphene citrate (CC) has been suggested to increase the chance of sperm retrieval with microdissection testicular sperm extraction (micro-TESE).


Objective: This study aimed to evaluate the effect of CC on micro-TESE results, due to the great controversy in this regard.


Materials and Methods: 112 participants were included in this cross-sectional study and were divided into a case (n = 54) and a control group (n = 58) diagnosed with non-abstractive azoospermia. The case group received 25 mg of CC daily for 3 months, while the control group did not receive anything. All participants underwent micro-TESE by an andrologist, and at the end, the results were compared between groups. Hormone tests, including follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin were analyzed.


Results: The mean age of participants was the same in the case and the control groups, and no significant relationship was observed between the 2 groups (p = 0.16). 25.9% of sperm and 31.0% of sperm were observed and extracted in the CC-treated and the control group, respectively.


Conclusion: Our findings showed that after receiving CC, the number of sperm extraction did not increase but it rather decreased. However, the initial level of hormones such as testosterone, follicle-stimulating hormone, luteinizing hormone, and prolactin, and the men’s age, testicle size, smoking, and opium addiction, underlying diseases had no significant relationship in the 2 groups and did not affect the results.


Key words: Azoospermia, Clomiphene, Male infertility, Sperm retrieval.

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