https://doi.org/10.18502/ijrm.v21i10.14539
statistics
- 76 Abstract Views
- 48 PDF Views
- 0 HTML Views
authors
-
Ali Taheri Madah
Ali Taheri Madah
Department of Anatomical Science and Research Center, Aja University of Medical Sciences, Tehran, Iran.
-
Saeid Hadi
Saeid Hadi
Department of Health and Nutrition, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
-
Beheshteh Abouhamzeh
Beheshteh Abouhamzeh
Department of Anatomical Science and Research Center, Aja University of Medical Sciences, Tehran, Iran.
-
Vahid Hadi
Vahid Hadi
Department of Health and Nutrition, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
-
Maasoume Abdollahi
Maasoume Abdollahi
Department of Anatomical Science and Research Center, Aja University of Medical Sciences, Tehran, Iran.
-
Kiumars Omidi
Kiumars Omidi
Department of Radiology, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Published Date
- Nov 21, 2023
The association between dietary inflammatory index and C-reactive protein in plasma and semen with semen quality: A cross-sectional study
Abstract
Background: Infertility affects couples worldwide, with male factors being responsible for half of all cases.
Objective: This study aimed to investigate the relationship between dietary inflammatory index (DII) and levels of C-reactive protein (CRP) in plasma and semen with the quality of semen in infertile males.
Materials and Methods: In this cross-sectional study, 88 infertile men referring to Besat hospital, Tehran, Iran from December 2021-November 2022 were enrolled. A detailed questionnaire requesting information, and a 168-item semiquantitative food frequency questionnaire, were completed by participants. A food frequency questionnaire was used to calculate the DII. Additionally, semen and blood samples were collected from each participant for semen analysis and CRP-level assessment. Statistical analyses were performed to explore the association between DII and CRP levels with sperm quality. The correlation between DII and serum/semen CRP, besides assessing nutrients in each DII quartile group, was also explored.
Results: A significant difference was observed between different DII quartiles considering sperm motility (p = 0.006) and morphology (p = 0.014). Post hoc study revealed a significant difference between the 1st and 2nd quartiles and the 1st and 4th quartiles of DII regarding sperm motility (p = 0.011, and 0.017 respectively) and a significant difference between the 1st and 2nd quartiles of DII considering sperm morphology (p = 0.009). A statistically significant inverse correlation was also observed between DII and sperm motility (p = 0.017). Carbohydrates and β-carotenes were significantly different between the 4 DII quartiles (p = 0.043 and p = 0.026, respectively). Finally, no significant correlation was observed between DII and CRP levels in blood and semen (p > 0.05).
Conclusion: The findings suggested a notable correlation between DII and semen quality; however, no significant association were observed between DII and CRP levels in blood and semen.
Key words: Infertility, C-reactive protein, CRP, Inflammation, Sperm.
References
[2] Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem 2018; 62: 2–10.
[3] Mazzilli R, Medenica S, Di Tommaso AM, Fabozzi G, Zamponi V, Cimadomo D, et al. The role of thyroid function in female and male infertility: A narrative review. J Endocrinol Invest 2023; 46: 15–26.
[4] Leaver RB. Male infertility: An overview of causes and treatment options. Br J Nurs 2016; 25: S35–S40.
[5] Nassan FL, Jensen TK, Priskorn L, Halldorsson TI, Chavarro JE, Jorgensen N. Association of dietary patterns with testicular function in Young Danish Men. JAMA Netw Open 2020; 3: e1921610.
[6] Maric T, Fucic A, Aghayanian A. Environmental and occupational exposures associated with male infertility. Arh Hig Rada Toksikol 2021; 72: 101–113.
[7] Mann JM, Wei C, Chen C. How genetic defects in piRNA trimming contribute to male infertility. Andrology 2023; 11: 911–917.
[8] Burke ND, Nixon B, Roman SD, Schjenken JE, Walters JL, Aitken RJ, et al. Male infertility and somatic health-insights into lipid damage as a mechanistic link. Nat Rev Urol 2022; 19: 727–750.
[9] Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. J Reprod Infertil 2015; 16: 123– 129.
[10] Fang Y, Su Y, Xu J, Hu Z, Zhao K, Liu C, et al. Varicocele-mediated male infertility: From the perspective of testicular immunity and inflammation. Front Immunol 2021; 12: 729539.
[11] Dutta S, Sengupta P, Slama P, Roychoudhury S. Oxidative stress, testicular inflammatory pathways, and male reproduction. Int J Mol Sci 2021; 22: 10043.
[12] Agarwal A, Rana M, Qiu E, AlBunni H, Bui AD, Henkel R. Role of oxidative stress, infection and inflammation in male infertility. Andrologia 2018; 50: e13126.
[13] Ojo OA, Nwafor-Ezeh PI, Rotimi DE, Iyobhebhe M, Ogunlakin AD, Ojo AB. Apoptosis, inflammation, and oxidative stress in infertility: A mini review. Toxicol Rep 2023; 10: 448–462.
[14] Salas-Huetos A, Bullo M, Salas-Salvado J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: A systematic review of observational studies. Hum Reprod Update 2017; 23: 371–389.
[15] Jurewicz J, Radwan M, Sobala W, Radwan P, Bochenek M, Hanke W. Dietary patterns and their relationship with semen quality. Am J Mens Health 2018; 12: 575–583.
[16] Ferramosca A, Zara V. Diet and male fertility: The impact of nutrients and antioxidants on sperm energetic metabolism. Int J Mol Sci 2022; 23: 2542.
[17] Skoracka K, Eder P, Lykowska-Szuber L, Dobrowolska A, Krela-Kazmierczak I. Diet and nutritional factors in male (In)fertility-underestimated factors. J Clin Med 2020; 9: 1400.
[18] Zhang C, Ren W, Li M, Wang W, Sun C, Liu L, et al. Association between the children’s dietary inflammatory index (C-DII) and markers of inflammation and oxidative stress among children and adolescents: NHANES 2015– 2018. Front Nutr 2022; 9: 894966.
[19] Abd El Salam MA. Obesity, an enemy of male fertility: A mini review. Oman Med J 2018; 33: 3–6.
[20] Nehring SM, Goyal A, Patel BC. C reactive protein. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
[21] Shivappa N, Steck SE, Hurley TG, Hussey JR, Hebert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr 2014; 17: 1689–1696.
[22] Shivappa N, Hebert JR, Rietzschel ER, De Buyzere ML, Langlois M, Debruyne E, et al. Associations between dietary inflammatory index and inflammatory markers in the asklepios study. Br J Nutr 2015; 113: 665–671.
[23] Bjorndahl L, Kirkman Brown J. The sixth edition of the WHO laboratory manual for the examination and processing of human semen: Ensuring quality and standardization in basic examination of human ejaculates. Fertil Steril 2022; 117: 246–251.
[24] Hosseini Esfahani F, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran lipid and glucose study. J Epidemiol 2010; 20: 150–158.
[25] Bukharin OV, Perunova NB, Ivanova EV, Chaynikova IN, Bekpergenova AV, Bondarenko TA, et al. Semen microbiota and cytokines of healthy and infertile men. Asian J Androl 2022; 24: 353–358.
[26] Hasan H, Bhushan S, Fijak M, Meinhardt A. Mechanism of inflammatory associated impairment of sperm function, spermatogenesis and steroidogenesis. Front Endocrinol 2022; 13: 897029.
[27] Smidowicz A, Regula J. Effect of nutritional status and dietary patterns on human serum C-reactive protein and interleukin-6 concentrations. Adv Nutr 2015; 6: 738–747.
[28] Neale EP, Batterham MJ, Tapsell LC. Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: A meta-analysis. Nutr Res 2016; 36: 391–401.
[29] Adoamnei E, Cutillas-Tolin A, Mendiola J, Lopez-Espin JJ, Shivappa N, Vioque J, et al. [Associations between dietary inflammatory index and male reproductive parameters]. Rev Int Androl 2019; 17: 79–87. (In Spanish)
[30] Adoamnei E, Mendiola J, Monino-Garcia M, Lopez- Espin JJ, Navarrete-Munoz EM, Torres-Cantero AM. [Dietary intake of trace elements and semen quality and reproductive hormone levels in young men: Relationship with fertility]. Rev Int Androl 2019; 17: 46–54. (In Spanish)
[31] Cutillas-Tolin A, Adoamnei E, Navarrete-Munoz EM, Vioque J, Monino-Garcia M, Jorgensen N, et al. Adherence to diet quality indices in relation to semen quality and reproductive hormones in young men. Hum Reprod 2019; 34: 1866–1875.
[32] Ognjenovic M, Ambrosini GL, Malacova E, Doherty DA, Oddy WH, Handelsman DJ, et al. Associations between major dietary patterns and testicular function in a population-based cohort of young men: Results from the western australian pregnancy cohort (Raine) study. Andrology 2019; 7: 273–280.
[33] Oostingh EC, Steegers-Theunissen RPM, de Vries JHM, Laven JSE, Koster MPH. Strong adherence to a healthy dietary pattern is associated with better semen quality, especially in men with poor semen quality. Fertil Steril 2017; 107: 916–923. e2.
[34] Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N. Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 2017; 32: 215–222.
[35] Liu C-Y, Chou Y-C, Chao JC-J, Hsu C-Y, Cha T-L, Tsao CW. The association between dietary patterns and semen quality in a general asian population of 7282 males. PLoS One 2015; 10: e0134224.