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Yazdizadeh, M., Hivehchi, N., Ghaemi, M., Azizi, S., Saeedzarandi, M., Afrooz, N., Keshavarz, P., Ansarin, M., Fakehi, M., Yazdizadeh, M., & Mokhtari, M. (2023). Platelet to lymphocyte and neutrophil to lymphocyte ratio in the first trimester of pregnancy, are they useful for predicting spontaneous miscarriage? A case-control study. International Journal of Reproductive BioMedicine (IJRM), 21(6), 463–470. https://doi.org/10.18502/ijrm.v21i6.13632

https://doi.org/10.18502/ijrm.v21i6.13632

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authors

  • Maryam Yazdizadeh

    Maryam Yazdizadeh

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Nafisseh Hivehchi

    Nafisseh Hivehchi

    Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Marjan Ghaemi

    Marjan Ghaemi

    Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Sepideh Azizi

    Sepideh Azizi

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Maryam Saeedzarandi

    Maryam Saeedzarandi

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Narjes Afrooz

    Narjes Afrooz

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Pegah Keshavarz

    Pegah Keshavarz

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Melika Ansarin

    Melika Ansarin

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Maliheh Fakehi

    Maliheh Fakehi

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Mina Yazdizadeh

    Mina Yazdizadeh

    Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
  • Mojgan Mokhtari

    Mojgan Mokhtari

    Shahid Akbarabadi Clinical Research Development Unit, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Published Date

  • Jul 19, 2023

Platelet to lymphocyte and neutrophil to lymphocyte ratio in the first trimester of pregnancy, are they useful for predicting spontaneous miscarriage? A case-control study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 21, Issue No. 6 / Pages 463–470

Abstract

Background: In 15% of all clinical pregnancies, a miscarriage can occur, but the exact cause of this phenomenon is not fully understood. However, it is believed that a faulty placenta, which triggers an inflammatory response in the mother’s body, may be one of the causes. Medical literature has increasingly focused on 2 indicators of inflammation, the plateletlymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR). Despite this, there has yet to be a study conducted that examines the rates of PLR and NLR in cases of miscarriage.


Objective: This study aims to determine whether there is an increase in complete blood count inflammatory parameters such as NLR and PLR in women who experience miscarriages.


Materials and Methods: This retrospective case-control study was conducted from March 2021 to March 2022, across 3 academic hospitals in Tehran, Iran. A total of 240 participants were enrolled comprising individuals with either miscarriages or normal pregnancies (n = 120/each). Data were collected from the medical records of participants aged between 18-42 yr old, with gestational age ranging from 6-13 wk. The demographic information, including age, body mass index, parity, history of abortion, number of abortions, number of living children, hematocrit and hemoglobin levels, platelet distribution width (PDW), PLR, NLR, mean platelet volume, and platelet were extracted from their records. The gestational age was also recorded.


Results: A total of 240 participants were recruited for the study. PDW, NLR, PLR, and lymphocyte values were higher in the miscarriage group compared to the healthy normal pregnant women (p < 0.001). Mean platelet volumes were found to be lower in the miscarriage group compared to the healthy normal pregnant women (p < 0.001).


Conclusion: Although, no statistically significant difference was observed in the hemoglobin, hematocrit, platelets, and neutrophils in these 2 groups of pregnant women. The higher inflammatory markers including PDW, NLR, and PLR could potentially aid in the speculation of defective placentation as a contributing factor to the development of miscarriage. Measurement of these markers may be useful to predict pregnancy leading to miscarriage.


Key words: Spontaneous abortion, Inflammation, Neutrophils, Lymphocytes, Blood platelet, Pregnancy.

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