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Roshanzadeh, G., Jahanian Sadatmahalleh, S., Moini, A., Mottaghi, A., & Rostami, F. (2023). The relationship between dietary micronutrients and endometriosis: A case-control study. International Journal of Reproductive BioMedicine (IJRM), 21(4), 333–342. https://doi.org/10.18502/ijrm.v21i4.13272
https://doi.org/10.18502/ijrm.v21i4.13272
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- Cited by 2 articles
authors
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Ghazal Roshanzadeh
Ghazal Roshanzadeh
Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
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Shahideh Jahanian Sadatmahalleh
Shahideh Jahanian Sadatmahalleh
Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
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Ashraf Moini
Ashraf Moini
Department of Obstetrics and Gynecology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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Azadeh Mottaghi
Azadeh Mottaghi
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
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Farahnaz Rostami
Farahnaz Rostami
Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Published Date
- May 6, 2023
The relationship between dietary micronutrients and endometriosis: A case-control study
Abstract
Background: Fewer studies were on micronutrient intake in women with endometriosis, and the etiology of endometriosis remains unclear between dietary micronutrients and the risk of endometriosis.
Objective: This study aimed to investigate the relationship between dietary micronutrients and the risk of endometriosis.
Materials and Methods: This case-control study was conducted on 156 women (18-45 yr) with and without endometriosis in the gynecology clinic of Arash hospital between May 2017 and May 2018 in Tehran, Iran. According to the laparoscopic findings, the participants were divided into 2 groups (n = 78/each), women with pelvic endometriosis as the case group and women without endometriosis pelvic as the control group. Dietary data were collected using a validated 168-item semiquantitative food frequency questionnaire with the standard serving. A logistic regression model was used to determine the association between micronutrients and the risk of endometriosis.
Results: Data analysis showed a significant relationship between micronutrients such as: potassium (OR: 0.74; CI: 0.56-0.99; p = 0.01), calcium (OR: 0.70; CI: 0.52-0.94; p = 0.003), and also among the vitamin C (OR: 0.70; CI: 0.52-0.94; p = 0.02), B2 (OR: 0.73; CI: 0.55-0.98; p = 0.01), and B12 (OR: 0.71; CI: 0.53-0.95; p = 0.02) with endometriosis, so those who used fewer micronutrients were at higher risk of endometriosis.
Conclusion: The findings showed that the dietary intakes of calcium, potassium, vitamins B12, B2, B6, and C are inversely related to the risk of endometriosis.
Key words: Diet, Endometriosis, Food questionary, Micronutrients
References
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[18] Youseflu S, Jahanian Sadatmahalleh Sh, Mottaghi A, Kazemnejad A. Dietary phytoestrogen intake and the risk of endometriosis in Iranian women: A case-control study. Int J Fertil Steril 2020; 13: 296–300.
[19] Vitale SG, Capriglione S, Peterlunger I, La Rosa VL, Vitagliano A, Noventa M, et al. The role of oxidative stress and membrane transport systems during endometriosis: A fresh look at a busy corner. Oxidative medicine and cellular longevity. Oxid Med Cell Longe 2018; 2018: 7924021.
[20] Jurkiewicz-Przondziono J, Lemm M, Kwiatkowska-Pamuła A, Ziółko E, Wójtowicz MK. Influence of diet on the risk of developing endometriosis. Ginekol Pol 2017; 88: 96–102.
[21] Ashrafi M, Jahangiri N, Jahanian Sadatmahalleh Sh, Aliani F, Akhoond MR. Diet and the risk of endometriosis in iranian women: A case-control study. Int J Fertil Steril 2020; 14: 193–200.
[22] Schink M, Konturek PC, Herbert SL, Renner SP, Burghaus S, Blum S, et al. Different nutrient intake and prevalence of gastrointestinal comorbidities in women with endometriosis. J Physiol Pharmacol 2019; 70: 255–268.
[23] Raindi D. Nutrition and periodontal disease. Dent Update 2016; 43: 66–72.
[24] Aversa R, Petrescu RV, Apicella A, Petrescu FI. We are addicted to vitamins C and E-A review. Am J Eng Appl Sci 2016; 9: 1003–1018.
[25] Shi XJ, Shi LB, Zhang SY. Mechanistic study of vitamin C attenuation of endometriotic fibrosis. Clin Exp Obstet Gynecol 2020; 47: 383–390.
[26] Simmen RCM, Kelley AS. Seeing red: Diet and endometriosis risk. Ann Transl Med 2018; 6 (Suppl.): S119.
[27] Halpern G, Schor E, Kopelman A. Nutritional aspects related to endometriosis. Rev Assoc Med Bras 2015; 61: 519–523.
[28] Ghasemian Langharodi S, Farzanegi P, Moradi L. [The effect of swimming training and vitamin B6 intake on GATA2 gene expression in endometriosis rat]. J Ardabil Univ Med Sci 2019; 19: 354–365. (In Persian)
[29] Ghasemian Langrodi S, Farzanegi P, Moradi L. [The effect of swimming training and vitamin B6 intake on ALDH1A2 gene expression in endometriosis rat]. Razi J Med Sci 2021; 28: 152–162. (In Persian)
[30] Prego-Dominguez J, Hadrya F, Takkouche B. Polyunsaturated fatty acids and chronic pain: A systematic review and meta-analysis. Pain Physician 2016; 19: 521–535.
[31] Paliga M, Horák S. Relationship between endometriosis and vitamin D status-a review. Clin Exp Obstet Gynecol 2019; 46: 674–678.
[32] Guo M, Bafligil C, Tapmeier T, Hubbard C, Manek S, Shang C, et al. Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: A characterisation study. BMC Med 2020; 18: 3.
[2] Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur J Obstet Gynecol Reprod Biol 2017; 209: 3–7.
[3] Xiong W, Zhang L, Yu L, Xie W, Man Y, Xiong Y, et al. Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis. Reproduction 2015; 150: 507–516.
[4] Kuznetsov L, Dworzynski K, Davies M, Overton C, Guideline Committee. Diagnosis and management of endometriosis: Summary of NICE guidance. BMJ 2017; 358: j3935.
[5] Jain A, Tiwari A, Verma A, Jain SK. Vitamins for cancer prevention and treatment: An insight. Curr Mol Med 2017; 17: 321–340.
[6] Sinha A, Gupta S. The role of antioxidant supplementation in endometriosis therapy. J Gynecol Women’s Health 2017; 3: 555601.
[7] Sehsah FIA, Abd El-Fattah AT, Saeed AM. The role of antioxidant supplementation in reducing the endometriosis related chronic pelvic pain in women. Al-Azhar Med J 2022; 51: 121–134.
[8] Vlachos A, Vassiliadis S. The immunological impact of orthomolecular medicine using bioactive compounds as key factors in endometriosis. Bioact Compound Health Dis 2019; 25: 1–10.
[9] Donnez J, Binda MM, Donnez O, Dolmans M-M. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril 2016; 106: 1011–1017.
[10] Jin L, Lorkiewicz P, Malovichko MV, Bhatnagar A, Srivastava S, Conklin DJ. Acetaldehyde induces an endothelium-dependent relaxation of superior mesenteric artery: Potential role in postprandial hyperemia. Front Physiol 2019; 10: 1315.
[11] Lee HJ, Noh HK, Kim SC, Joo JK, Suh DS, Kim KH. Dietary pattern and risk endometrioma in Korean women: A casecontrol study. Obstet Gynecol Sci 2021; 64: 99–106.
[12] Huijs E, Nap A. The effects of nutrients on symptoms in women with endometriosis: A systematic review. Reprod BioMed Online 2020; 41: 317–328.
[13] Lee SY, Koo YJ, Lee DH. Classification of endometriosis. Yeungnam Univ J Med 2021; 38: 10–18.
[14] Savaris AL, do Amaral VF. Nutrient intake, anthropometric data and correlations with the systemic antioxidant capacity of women with pelvic endometriosis. Eur J Obstet Gynocol Reprod Biol 2011; 158: 314–318.
[15] Youseflu S, Jahanian Sadatmahalleh Sh, Mottaghi A, Kazemnejad A. The association of food consumption and nutrient intake with endometriosis risk in Iranian women: A case-control study. Int J Reprod BioMed 2019; 17: 661–670.
[16] Nikniaz L, Tabrizi J, Sadeghi-Bazargani H, Farahbakhsh M, Tahmasebi S, Noroozi S. Reliability and relative validity of short-food frequency questionnaire. Br Food J 2017; 119: 1337–1348.
[17] Nodler JL, Harris HR, Chavarro JE, Frazier AL, Missmer SA. Dairy consumption during adolescence and endometriosis risk. Am J Obstet Gynocol 2020; 222: 257.
[18] Youseflu S, Jahanian Sadatmahalleh Sh, Mottaghi A, Kazemnejad A. Dietary phytoestrogen intake and the risk of endometriosis in Iranian women: A case-control study. Int J Fertil Steril 2020; 13: 296–300.
[19] Vitale SG, Capriglione S, Peterlunger I, La Rosa VL, Vitagliano A, Noventa M, et al. The role of oxidative stress and membrane transport systems during endometriosis: A fresh look at a busy corner. Oxidative medicine and cellular longevity. Oxid Med Cell Longe 2018; 2018: 7924021.
[20] Jurkiewicz-Przondziono J, Lemm M, Kwiatkowska-Pamuła A, Ziółko E, Wójtowicz MK. Influence of diet on the risk of developing endometriosis. Ginekol Pol 2017; 88: 96–102.
[21] Ashrafi M, Jahangiri N, Jahanian Sadatmahalleh Sh, Aliani F, Akhoond MR. Diet and the risk of endometriosis in iranian women: A case-control study. Int J Fertil Steril 2020; 14: 193–200.
[22] Schink M, Konturek PC, Herbert SL, Renner SP, Burghaus S, Blum S, et al. Different nutrient intake and prevalence of gastrointestinal comorbidities in women with endometriosis. J Physiol Pharmacol 2019; 70: 255–268.
[23] Raindi D. Nutrition and periodontal disease. Dent Update 2016; 43: 66–72.
[24] Aversa R, Petrescu RV, Apicella A, Petrescu FI. We are addicted to vitamins C and E-A review. Am J Eng Appl Sci 2016; 9: 1003–1018.
[25] Shi XJ, Shi LB, Zhang SY. Mechanistic study of vitamin C attenuation of endometriotic fibrosis. Clin Exp Obstet Gynecol 2020; 47: 383–390.
[26] Simmen RCM, Kelley AS. Seeing red: Diet and endometriosis risk. Ann Transl Med 2018; 6 (Suppl.): S119.
[27] Halpern G, Schor E, Kopelman A. Nutritional aspects related to endometriosis. Rev Assoc Med Bras 2015; 61: 519–523.
[28] Ghasemian Langharodi S, Farzanegi P, Moradi L. [The effect of swimming training and vitamin B6 intake on GATA2 gene expression in endometriosis rat]. J Ardabil Univ Med Sci 2019; 19: 354–365. (In Persian)
[29] Ghasemian Langrodi S, Farzanegi P, Moradi L. [The effect of swimming training and vitamin B6 intake on ALDH1A2 gene expression in endometriosis rat]. Razi J Med Sci 2021; 28: 152–162. (In Persian)
[30] Prego-Dominguez J, Hadrya F, Takkouche B. Polyunsaturated fatty acids and chronic pain: A systematic review and meta-analysis. Pain Physician 2016; 19: 521–535.
[31] Paliga M, Horák S. Relationship between endometriosis and vitamin D status-a review. Clin Exp Obstet Gynecol 2019; 46: 674–678.
[32] Guo M, Bafligil C, Tapmeier T, Hubbard C, Manek S, Shang C, et al. Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: A characterisation study. BMC Med 2020; 18: 3.