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Seyedoshohadaei, F., Abbasi, S., Rezaie, M., Allahvaisi, A., Rezaie, M. J., Soufizadeh, N., & Rahmani, K. (2022). Myo-inositol effect on pregnancy outcomes in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: A double-blind RCT. International Journal of Reproductive BioMedicine (IJRM), 20(8), 643–650. https://doi.org/10.18502/ijrm.v20i8.11753

https://doi.org/10.18502/ijrm.v20i8.11753

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authors

  • Fariba Seyedoshohadaei

    Fariba Seyedoshohadaei

    Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Shahin Abbasi

    Shahin Abbasi

    Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Masoumeh Rezaie

    Masoumeh Rezaie

    Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Azra Allahvaisi

    Azra Allahvaisi

    Infertility Treatment Center of Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Mohammad Jafar Rezaie

    Mohammad Jafar Rezaie

    Infertility Treatment Center of Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Nasrin Soufizadeh

    Nasrin Soufizadeh

    Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Khaled Rahmani

    Khaled Rahmani

    Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

Published Date

  • Sep 6, 2022

Myo-inositol effect on pregnancy outcomes in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: A double-blind RCT

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 20, Issue No. 8 / Pages 643–650

Abstract

Background: Myo-inositol is an intracellular mediator which is involved in various aspects of reproduction in women.


Objective: This study aimed to evaluate the impact of Myo-inositol on the outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles in infertile women.


Materials and Methods: This double-blind randomized controlled trial was conducted on 70 infertile women referred to the Infertility Treatment Center, Besat hospital, Sanandaj, Iran from May 2019 to September 2019 for IVF/ICSI cycles. The participants were randomly divided into 2 intervention (n = 36) and control (n = 34) groups. The intervention group received 2000 mg of Myo-inositol and 200 mcg folic acid twice a day for 2 months and the control group received 200 mcg of folic acid twice a day for 2 months in the IVF/ICSI cycles (from the third day of cycle until the end of the second month). Finally, the number of oocytes, the quality of embryos, and the IVF/ICSI outcomes were compared between the 2 groups.


Results: The mean numbers of oocytes, MII oocytes, and 2 pronuclear embryos were significantly higher in the intervention group than the control group. Also, the clinical pregnancy and live birth rates in the intervention group were significantly higher than in the controls (p = 0.04).


Conclusion: The administration of Myo-inositol may increase clinical pregnancy and live birth rates by increasing the number of total and meiosis II oocytes in infertile women undergoing IVF/ICSI.


Key words: Infertility, In vitro fertilization, Intracytoplasmic sperm injection, Myoinositol.

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