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Maghsoumi-Norouzabad, L., Labibzadeh, M., Zare Javid, A., Ahmad Hosseini, S., Abbas Kaydani, G., & Dastoorpur, M. (2022). The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study. International Journal of Reproductive BioMedicine (IJRM), 20(4), 331-338. https://doi.org/10.18502/ijrm.v20i4.10905

https://doi.org/10.18502/ijrm.v20i4.10905

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  • Cited by 2 articles

authors

  • Leila Maghsoumi-Norouzabad

    Leila Maghsoumi-Norouzabad

    Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Maryam Labibzadeh

    Maryam Labibzadeh

    Center of Therapy and Research Infertility Jahad Daneshgahi, Ahvaz, Iran.
  • Ahmad Zare Javid

    Ahmad Zare Javid

    Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Seyed Ahmad Hosseini

    Seyed Ahmad Hosseini

    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Gholam Abbas Kaydani

    Gholam Abbas Kaydani

    Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Maryam Dastoorpur

    Maryam Dastoorpur

    Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Published Date

  • May 23, 2022

The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 20, Issue No. 4 / Pages 331-338

Abstract

Background: The prevalence of vitamin D deficiency and male infertility is high in Iran.


Objective: The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men.


Materials and Methods: This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient (< 10 ng/mL), insufficient (10 ng/mL ≤ 25(OH)D ≤ 30 ng/mL), and sufficient (> 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed.


Results: The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < 0.001). Also, in the sufficient group, serum LH (p < 0.001) and estradiol (p < 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p < 0.001) and the testosterone/LH ratio (p < 0.001) were considerably higher compared to the insufficient and deficient groups.


Conclusion: Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.


Key words: Infertility, Male, Vitamin D, Semen analysis, Gonadal hormones, Pituitary hormones.

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