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Efremova, O., Ponomarenko, I., & Churnosov, M. (2022). Maternal polymorphic loci of rs1979277 serine hydroxymethyl transferase and rs1805087 5-methylenetetrahydrofolate are correlated with the development of fetal growth restriction: A case-control study. International Journal of Reproductive BioMedicine (IJRM), 19(12), 1067-1074. https://doi.org/10.18502/ijrm.v19i12.10057
https://doi.org/10.18502/ijrm.v19i12.10057
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Olesya Efremova
Olesya Efremova
Department of Biomedical Disciplines, Belgorod State University, Belgorod, Russia.
-
Irina Ponomarenko
Irina Ponomarenko
Department of Biomedical Disciplines, Belgorod State University, Belgorod, Russia.
-
Mikhail Churnosov
Mikhail Churnosov
Department of Biomedical Disciplines, Belgorod State University, Belgorod, Russia.
Published Date
- Jan 12, 2022
Maternal polymorphic loci of rs1979277 serine hydroxymethyl transferase and rs1805087 5-methylenetetrahydrofolate are correlated with the development of fetal growth restriction: A case-control study
Abstract
Background: Key reactions in folate-mediated single-carbon metabolism are regulated by folate cycle enzymes. Violations of the folate cycle may be associated with the occurrence of fetal growth restriction (FGR) in pregnant women.
Objective: To study the relationship between polymorphisms of folate cycle genes in the mother with the development of FGR.
Materials and Methods: In this case-control study, 122 pregnant women with FGR and 243 pregnant women with normal newborn weight were enrolled. The polymorphic loci of folate cycle genes including rs1805087 5-methylenetetrahydrofolate (MTR) and rs1979277 serine hydroxymethyl transferase (SHMT1) were examined. The study of polymorphisms was carried out through the TaqMan probe detection method using polymerase chain reaction. Logistic regression was used to analyze the associations of the polymorphisms.
Results: It was established that the T allele rs1979277 of the SHMT1 gene was correlated with the development of FGR within the framework of the allelic (OR = 1.67, 95% CI 1.20-2.33, pperm < 0.01), additive (OR = 1.69, 95% CI 1.20-2.37, pperm < 0.01), dominant (OR = 1.81, 95% CI 1.15-2.87, pperm = 0.01) and recessive (OR = 2.34, 95% CI 1.15-4.73, pperm = 0.01) models. The association of the G rs1805087 allele of the MTR gene with the occurrence of FGR was also identified following the recessive model (OR = 3.01, 95% CI 1.05-8.68, pperm = 0.04).
Conclusion: Our results indicated that maternal polymorphic loci rs1979277 SHMT1 and rs1805087 MTR may be associated with the development of FGR.
Key words: Polymorphism, Associations, Fetal growth restriction, Folic acid.
References
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[19] Liu HY, Liu SM, Zhang YZ. Maternal folic acid supplementation mediates offspring health via DNA methylation. Reprod Sci 2020; 27: 963–976.
[20] Stanislawska-Sachadyn A, Borzyszkowska J, Krzeminski M, Janowicz A, Dziadziuszko R, Jassem J, et al. Folate/homocysteine metabolism and lung cancer risk among smokers. PLoS One 2019; 14: e0214462.
[21] Deng C, Tang Sh, Huang X, Gao J, Tian J, Zhou X, et al. Identification of three novel loci of ALDH2 gene for serum folate levels in a male Chinese population by genome-wide association study. Gene 2018; 674: 121–126.
[22] Salarkia E, Sepehri Gh, Torabzadeh P, Abshenas J, Saberi A. Effects of administration of co-trimoxazole and folic acid on sperm quality and histological changes of testes in male rats. Int J Reprod Biomed 2017; 15: 625–634.
[23] Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed 2016; 14: 729–736.
[24] Ferreira FR, Akiba HRR, Araujo Júnior E, Figueiredo EN, Abrahão AR. Prevention of birth defects in the pre-conception period: Knowledge and practice of health care professionals (nurses and doctors) in a city of Southern Brazil. Iran J Reprod Med 2015; 13: 657–664.
[25] Tanoomand A, Hajibemani A, Abouhamzeh B. Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene. Clin Exp Reprod Med 2019; 46: 107–111.
[26] Coppedè F, Stoccoro A, Tannorella P, Migliore L. Plasma homocysteine and polymorphisms of genes involved in folate metabolism correlate with DNMT1 gene methylation levels. Metabolites 2019; 9: 298.
[27] Fang Y, Zhang R, Zhi X, Zhao L, Cao L, Wang Y, et al. Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China. Childs Nerv Syst 2018; 34: 725–729.
[28] Fekete K, Berti C, Cetin I, Hermoso M, Koletzko BV, Decsi T. Perinatal folate supply: Relevance in health outcome parameters. Matern Child Nutr 2010; 6 (Suppl.): 23–38.
[29] Qu YY, Zhou ShX, Zhang X, Zhao R, Gu ChY, Chang K, et al. Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population. Sci Rep 2016; 6: 36264.
[30] Wang C, Lu D, Ling Q, Chen J, Liu Zh, Guo H, et al. Donor one-carbon metabolism gene single nucleotide polymorphisms predict the susceptibility of cancer recurrence after liver transplantation. Gene 2019; 689: 97–101.
[31] Bahari G, Hashemi M, Naderi M, Sadeghi-Bojd S, Taheri M. Association of SHMT1 gene polymorphisms with the risk of childhood acute lymphoblastic leukemia in a sample of Iranian population. Cell Mol Biol 2016; 62: 45–51.
[32] Nazari Mehrabani SZ, Shushizadeh MH, Abazari MF, Nouri Aleagha M, Ardalan A, Abdollahzadeh R, et al. Association of SHMT1, MAZ, ERG, and L3MBTL3 gene polymorphisms with susceptibility to multiple sclerosis. Biochem Genet 2019; 57: 355–370.
[33] Salamanca C, González-Hormazábal P, Recabarren AS, Recabarren PA, Pantoja R, Leiva N, et al. A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile. Oral Dis 2020; 26: 159–165.
[34] Rebekah KP, Tella S, Buragadda S, Tiruvatturu MK, Akka J. Interaction between maternal and paternal SHMT1 C1420T predisposes to neural tube defects in the fetus: Evidence from case-control and family-based triad approaches. Birth Defects Res 2017; 109: 1020–1029.
[2] Williams PJ, Bulmer JN, Innes BA, Broughton Pipkin F. Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biol Reprod 2011; 84: 1148–1153.
[3] Field MS, Kamynina E, Chon J, Stover PJ. Nuclear folate metabolism. Ann Rev Nutr 2018; 38: 219–243.
[4] Rosario FJ, Nathanielsz PW, Powell ThL, Jansson Th. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep 2017; 7: 3982.
[5] Lokeswara AW, Hiksas R, Irwinda R, Wibowo N. Preeclampsia: From cellular wellness to inappropriate cell death, and the roles of nutrition. Front Cell Dev Biol 2021; 9: 726513.
[6] Reshetnikov E, Zarudskaya O, Polonikov A, Bushueva O, Orlova V, Krikun E, et al. Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia. J Obstet Gynaecol Res 2017; 43: 1139–1144.
[7] Golovchenko O, Abramova M, Ponomarenko I, Reshetnikov E, Aristova I, Polonikov A, et al. Functionally significant polymorphisms of ESR1 and PGR and risk of intrauterine growth restriction in population of Central Russia. Eur J Obstet Gynecol Reprod Biol 2020; 253: 52–57.
[8] Nardozza LMM, Caetano ACR, Zamarian ACP, Mozzalo JB, Silva CP, Marcal VMG, et al. Fetal growth restriction: Current knowledge. Arch Gynecol Obstet 2017; 295: 1061– 1077.
[9] Reshetnikov EA. [Study of associations of candidate genes differentially expressing in the placenta with the development of placental insufficiency with fetal growth restriction.] Res Result Biomed 2020; 6: 338–349. (in Russian)
[10] Gordijn SJ, Beune IM, Ganzevoort W. Building consensus and standards in fetal growth restriction studies. Best Pract Res Clin Obstet Gynaecol 2018; 49: 117–126.
[11] Jones P, Beckett E, Yates Z, Veysey M, Lucock M. Converging evolutionary, environmental and clinical ideas on folate metabolism. Exp Res Hypothes Med 2016; 1: 34– 41.
[12] Reshetnikov E, Ponomarenko I, Golovchenko O, Sorokina I, Batlutskaya I, Yakunchenko T, et al. The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy. Taiwan J Obstet Gynecol 2019; 58: 390–395.
[13] Ponomarenko I, Reshetnikov E, Polonikov A, Verzilina I, Sorokina I, Elgaeva EE, et al. Candidate genes for age at menarche are associated with endometriosis. Reprod Biomed Online 2020; 41: 943–956.
[14] Moskalenko M, Ponomarenko I, Reshetnikov E, Dvornyk V, Churnosov M. Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia. Sci Rep 2021; 11: 5224.
[15] Dvornyk V, Ponomarenko I, Minyaylo O, Reshetnikov E, Churnosov M. Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia. PLoS One 2021; 16: e0257060.
[16] Starikova D, Ponomarenko I, Reshetnikov E, Dvornyk V, Churnosov M. Novel data about association of the functionally significant polymorphisms of the MMP9 gene with exfoliation glaucoma in the Caucasian population of Central Russia. Ophthalmic Res 2021; 64: 458–464.
[17] Ponomarenko IV, Reshetnikov E, Altuchova O, Polonikov A, Sorokina I, Yermachenko A, et al. Association of genetic polymorphisms with age at menarche in Russian women. Gene 2019; 686: 228–236.
[18] Minyaylo O, Ponomarenko I, Reshetnikov E, Dvornyk V, Churnosov M. Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia. Sci Rep 2021; 11: 13515.
[19] Liu HY, Liu SM, Zhang YZ. Maternal folic acid supplementation mediates offspring health via DNA methylation. Reprod Sci 2020; 27: 963–976.
[20] Stanislawska-Sachadyn A, Borzyszkowska J, Krzeminski M, Janowicz A, Dziadziuszko R, Jassem J, et al. Folate/homocysteine metabolism and lung cancer risk among smokers. PLoS One 2019; 14: e0214462.
[21] Deng C, Tang Sh, Huang X, Gao J, Tian J, Zhou X, et al. Identification of three novel loci of ALDH2 gene for serum folate levels in a male Chinese population by genome-wide association study. Gene 2018; 674: 121–126.
[22] Salarkia E, Sepehri Gh, Torabzadeh P, Abshenas J, Saberi A. Effects of administration of co-trimoxazole and folic acid on sperm quality and histological changes of testes in male rats. Int J Reprod Biomed 2017; 15: 625–634.
[23] Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed 2016; 14: 729–736.
[24] Ferreira FR, Akiba HRR, Araujo Júnior E, Figueiredo EN, Abrahão AR. Prevention of birth defects in the pre-conception period: Knowledge and practice of health care professionals (nurses and doctors) in a city of Southern Brazil. Iran J Reprod Med 2015; 13: 657–664.
[25] Tanoomand A, Hajibemani A, Abouhamzeh B. Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene. Clin Exp Reprod Med 2019; 46: 107–111.
[26] Coppedè F, Stoccoro A, Tannorella P, Migliore L. Plasma homocysteine and polymorphisms of genes involved in folate metabolism correlate with DNMT1 gene methylation levels. Metabolites 2019; 9: 298.
[27] Fang Y, Zhang R, Zhi X, Zhao L, Cao L, Wang Y, et al. Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China. Childs Nerv Syst 2018; 34: 725–729.
[28] Fekete K, Berti C, Cetin I, Hermoso M, Koletzko BV, Decsi T. Perinatal folate supply: Relevance in health outcome parameters. Matern Child Nutr 2010; 6 (Suppl.): 23–38.
[29] Qu YY, Zhou ShX, Zhang X, Zhao R, Gu ChY, Chang K, et al. Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population. Sci Rep 2016; 6: 36264.
[30] Wang C, Lu D, Ling Q, Chen J, Liu Zh, Guo H, et al. Donor one-carbon metabolism gene single nucleotide polymorphisms predict the susceptibility of cancer recurrence after liver transplantation. Gene 2019; 689: 97–101.
[31] Bahari G, Hashemi M, Naderi M, Sadeghi-Bojd S, Taheri M. Association of SHMT1 gene polymorphisms with the risk of childhood acute lymphoblastic leukemia in a sample of Iranian population. Cell Mol Biol 2016; 62: 45–51.
[32] Nazari Mehrabani SZ, Shushizadeh MH, Abazari MF, Nouri Aleagha M, Ardalan A, Abdollahzadeh R, et al. Association of SHMT1, MAZ, ERG, and L3MBTL3 gene polymorphisms with susceptibility to multiple sclerosis. Biochem Genet 2019; 57: 355–370.
[33] Salamanca C, González-Hormazábal P, Recabarren AS, Recabarren PA, Pantoja R, Leiva N, et al. A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile. Oral Dis 2020; 26: 159–165.
[34] Rebekah KP, Tella S, Buragadda S, Tiruvatturu MK, Akka J. Interaction between maternal and paternal SHMT1 C1420T predisposes to neural tube defects in the fetus: Evidence from case-control and family-based triad approaches. Birth Defects Res 2017; 109: 1020–1029.