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Ashiq, K., Naureen, B., & Ashiq, S. (2021). Metal Complexes and Their Potential Therapeutic Role Against COVID-19: Recent Developments in Drug Designing. Sudan Journal of Medical Sciences (SJMS), 16(4), 540–545. https://doi.org/10.18502/sjms.v16i4.9951
https://doi.org/10.18502/sjms.v16i4.9951
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authors
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Kanwal Ashiq
Kanwal Ashiq
Faculty of Pharmaceutical Sciences, Superior University, Lahore, Pakistan
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Bushra Naureen
Bushra Naureen
Punjab University College of Pharmacy, University of the Punjab Lahore, Pakistan
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Sana Ashiq
Sana Ashiq
Department of Chemistry, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
Published Date
- Dec 31, 2021
Metal Complexes and Their Potential Therapeutic Role Against COVID-19: Recent Developments in Drug Designing
Abstract
COVID-19 is a global pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Being associated with high mortality rates, this pandemic has forced several countries worldwide to impose complete lockdowns to limit the spread of infection. Despite the development of various vaccines, there is still an urgent need to design novel treatments backed with safety data for fighting SARS-CoV-2 and its various mutants. Currently, scientists are putting their strenuous efforts into finding the best treatment option for COVID-19. In this regard, metal complexes being active antiviral agents and immunity enhancers have great potential against SARS-CoV-2. Herein, metal complexes' therapeutic role and significance against treating SARS-CoV-2 or any of its target proteins are discussed.
Keywords:
COVID-19, SARS-CoV-2, pandemic, metal complexes
References
[1] Chan, A. H. Y., Rutter , V., Ashiru-Oredope, D., et al. (2020). Together we unite: the role of the Commonwealth in achieving universal health coverage through pharmaceutical care amidst the COVID-19 pandemic. Journal of Pharmaceutical Policy and Practice, vol. 13, pp. 1–7.
[2] Ashiq, K., Bajwa, M. A., and Ashiq, S. (2021). COVID-19 pandemic and its impact on pharmacy education. Turkish Journal of Pharmaceutical Sciences, vol. 18, no. 2, pp. 122–123.
[3] Ashiq, K., Ashiq, S., Bajwa, M. A., et al. (2020). Knowledge, attitude and practices among the inhabitants of Lahore, Pakistan towards the COVID-19 pandemic: an immediate online based cross-sectional survey while people are under the lockdown. Bangladesh Journal of Medical Science, vol. 69, Special issue on COVID-19, pp. 69–76.
[4] Naureen, B. and Asghar, M. (2020). How to cope with COVID-19: global health and economic crisis. International Journal of Pharmacy and Integrated Health Science, vol. 1, no. 1, pp. 3–4.
[5] Halimi, V., Daci, A., Stojanovska, S., et al. (2020). Current regulatory approaches for accessing potential COVID-19 therapies. Journal of Pharmaceutical Policy and Practice, vol. 13, no. 1, pp. 1–4.
[6] Naureen, B., Miana, G., Shahid, K., et al. (2021). Iron (III) and zinc (II) monodentate Schiff base metal complexes: synthesis, characterisation and biological activities. Journal of Molecular Structure, vol. 1231, 129946.
[7] Tripathi, K. (2009). A review–can metal ions be incorporated into drugs? Asian Journal of Research in Chemistry, vol. 2, no. 1, pp. 14–18.
[8] Li, X., Shenashen, M. A., Wang, X., et al. (2017). Hierarchically porous, and Cu-and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy. Scientific Reports, vol. 7, no. 1, pp. 1–10.
[9] Cirri, D., Pratesi, A., Marzo, T., et al. (2021). Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs. Expert Opinion on Drug Discovery, vol. 16, no. 1, pp. 39–46.
[10] Vlasiou, M. C. and Pafti, K. S. (2021). Screening possible drug molecules for Covid-19. The example of vanadium (III/IV/V) complex molecules with computational chemistry and molecular docking. Computational Toxicology, vol. 18, 100157.
[11] Ali, A., Sepay, N., Afzal, M., et al. (2021). Molecular designing, crystal structure determination and in silico screening of copper (II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19. Bioorganic Chemistry, vol. 110, 104772.
[12] Almalki, S. A., Bawazeer, T. M., Asghar, B., et al. (2021). Synthesis and characterization of new thiazole-based Co (II) and Cu (II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocol. Journal of Molecular Structure, vol. 2021, 130961.
[13] Refat, M. S., Gaber, A., and Alsanie, W. F., (2021). Utilization and simulation of innovative new binuclear Co (ii), Ni (ii), Cu (ii), and Zn (ii) diimine Schiff base complexes in sterilization and coronavirus resistance (Covid-19). Open Chemistry, vol. 19, no. 1, pp. 772–784.
[14] Rad, A. S., Ardjmand, M., Esfahani, M. R., et al. (2021). DFT calculations towards the geometry optimization, electronic structure, infrared spectroscopy and UV–vis analyses of Favipiravir adsorption on the first-row transition metals doped fullerenes; a new strategy for COVID-19 therapy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 247, 119082.
[15] Refat, M. S, Altalhi, T., Bakare, S. B., et al. (2021). New Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Zn (II), Cd (II), and Hg (II) gibberellate complexes: synthesis, structure, and inhibitory activity against COVID-19 protease. Russian Journal of General Chemistry, vol. 91, no. 5, pp. 890–896.
[16] Mohamed, G. G.. Omar, M. M., and Ahmed, Y. M. (2021). Metal complexes of tridentate schiff base: synthesis, characterization, biological activity and molecular docking studies with COVID-19 protein receptor. Journal of Inorganic and General Chemistry, Online Version of Record before inclusion in an issue.
[17] Hecel, A., Ostrowska, M., Stokowa-Sołtys, K., et al. (2020). Zinc (II)—the overlooked éminence grise of chloroquine’s fight against COVID-19? Pharmaceuticals, vol. 13, no. 9, p. 228.
[18] Poupaert, J. H., Aguida, B., and Hountondji, C. (2020). Study of the interaction of zinc cation with azithromycin and its significance in the COVID-19 treatment: a molecular approach. The Open Biochemistry Journal, vol. 14, no. 1, pp. 33–40.
[2] Ashiq, K., Bajwa, M. A., and Ashiq, S. (2021). COVID-19 pandemic and its impact on pharmacy education. Turkish Journal of Pharmaceutical Sciences, vol. 18, no. 2, pp. 122–123.
[3] Ashiq, K., Ashiq, S., Bajwa, M. A., et al. (2020). Knowledge, attitude and practices among the inhabitants of Lahore, Pakistan towards the COVID-19 pandemic: an immediate online based cross-sectional survey while people are under the lockdown. Bangladesh Journal of Medical Science, vol. 69, Special issue on COVID-19, pp. 69–76.
[4] Naureen, B. and Asghar, M. (2020). How to cope with COVID-19: global health and economic crisis. International Journal of Pharmacy and Integrated Health Science, vol. 1, no. 1, pp. 3–4.
[5] Halimi, V., Daci, A., Stojanovska, S., et al. (2020). Current regulatory approaches for accessing potential COVID-19 therapies. Journal of Pharmaceutical Policy and Practice, vol. 13, no. 1, pp. 1–4.
[6] Naureen, B., Miana, G., Shahid, K., et al. (2021). Iron (III) and zinc (II) monodentate Schiff base metal complexes: synthesis, characterisation and biological activities. Journal of Molecular Structure, vol. 1231, 129946.
[7] Tripathi, K. (2009). A review–can metal ions be incorporated into drugs? Asian Journal of Research in Chemistry, vol. 2, no. 1, pp. 14–18.
[8] Li, X., Shenashen, M. A., Wang, X., et al. (2017). Hierarchically porous, and Cu-and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy. Scientific Reports, vol. 7, no. 1, pp. 1–10.
[9] Cirri, D., Pratesi, A., Marzo, T., et al. (2021). Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs. Expert Opinion on Drug Discovery, vol. 16, no. 1, pp. 39–46.
[10] Vlasiou, M. C. and Pafti, K. S. (2021). Screening possible drug molecules for Covid-19. The example of vanadium (III/IV/V) complex molecules with computational chemistry and molecular docking. Computational Toxicology, vol. 18, 100157.
[11] Ali, A., Sepay, N., Afzal, M., et al. (2021). Molecular designing, crystal structure determination and in silico screening of copper (II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19. Bioorganic Chemistry, vol. 110, 104772.
[12] Almalki, S. A., Bawazeer, T. M., Asghar, B., et al. (2021). Synthesis and characterization of new thiazole-based Co (II) and Cu (II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocol. Journal of Molecular Structure, vol. 2021, 130961.
[13] Refat, M. S., Gaber, A., and Alsanie, W. F., (2021). Utilization and simulation of innovative new binuclear Co (ii), Ni (ii), Cu (ii), and Zn (ii) diimine Schiff base complexes in sterilization and coronavirus resistance (Covid-19). Open Chemistry, vol. 19, no. 1, pp. 772–784.
[14] Rad, A. S., Ardjmand, M., Esfahani, M. R., et al. (2021). DFT calculations towards the geometry optimization, electronic structure, infrared spectroscopy and UV–vis analyses of Favipiravir adsorption on the first-row transition metals doped fullerenes; a new strategy for COVID-19 therapy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 247, 119082.
[15] Refat, M. S, Altalhi, T., Bakare, S. B., et al. (2021). New Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Zn (II), Cd (II), and Hg (II) gibberellate complexes: synthesis, structure, and inhibitory activity against COVID-19 protease. Russian Journal of General Chemistry, vol. 91, no. 5, pp. 890–896.
[16] Mohamed, G. G.. Omar, M. M., and Ahmed, Y. M. (2021). Metal complexes of tridentate schiff base: synthesis, characterization, biological activity and molecular docking studies with COVID-19 protein receptor. Journal of Inorganic and General Chemistry, Online Version of Record before inclusion in an issue.
[17] Hecel, A., Ostrowska, M., Stokowa-Sołtys, K., et al. (2020). Zinc (II)—the overlooked éminence grise of chloroquine’s fight against COVID-19? Pharmaceuticals, vol. 13, no. 9, p. 228.
[18] Poupaert, J. H., Aguida, B., and Hountondji, C. (2020). Study of the interaction of zinc cation with azithromycin and its significance in the COVID-19 treatment: a molecular approach. The Open Biochemistry Journal, vol. 14, no. 1, pp. 33–40.