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Dafalla, A. M., Dafalla, L. A., M. Ahmed, S., A. Mohammed, Y., D. Abakar, A., elbahar H. Aballah, W., Ahmed, E. A., & Modawe, G. (2020). Evaluation of the Efficiency of N-terminal Pro-B-type Natriuretic Peptide for Diagnosis of Acute Myocardial Infarction . Sudan Journal of Medical Sciences (SJMS), 15(3), 249–258. https://doi.org/10.18502/sjms.v15i3.7746

https://doi.org/10.18502/sjms.v15i3.7746

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authors

  • Abuagla M. Dafalla

    Abuagla M. Dafalla

    Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan
  • Leena A. Dafalla

    Leena A. Dafalla

    National Cancer Institute, University of Gezira, Sudan
  • ShamsEldein M. Ahmed

    ShamsEldein M. Ahmed

    Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan
  • Yousif A. Mohammed

    Yousif A. Mohammed

    National Cancer Institute, University of Gezira, Sudan
  • Adam D. Abakar

    Adam D. Abakar

    Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan
  • Wed elbahar H. Aballah

    Wed elbahar H. Aballah

    Department of hematology and immunohematology Faculty of Medical Laboratory Sciences, Managil University of Science and Technology Sudan
  • Elhadi A. Ahmed

    Elhadi A. Ahmed

    Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan
  • GadAllah Modawe

    GadAllah Modawe

    Department of Biochemistry, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Omdurman, Sudan

Published Date

  • Sep 30, 2020

Evaluation of the Efficiency of N-terminal Pro-B-type Natriuretic Peptide for Diagnosis of Acute Myocardial Infarction

Sudan Journal of Medical Sciences (SJMS) / Sudan JMS: Volume 15 (2020), Issue No. 3 / Pages 249–258

Abstract

Background: Cardiac diseases are one of the major causes of death worldwide with increasing incidence rate per year, particularly in developing countries such as Sudan owing to urbanization and changing lifestyle. Myocardial infarction is a consequence of the imbalance between the heart blood supply and the required heart cell; this disorder leads to necrosis of myocardium and may cause death. It could be diagnosed by at least two of the following criteria: chest pain, electrocardiography (ECG) elevation, and levels on cardiac biomarkers. This study aimed to evaluate the efficiency of N-terminal pro-B-type natriuretic peptide (NTproBNP) for the diagnosis of acute myocardial infarction (AMI).


 Methods: This analytical case–control hospital-based study was conducted on a total of 70 individuals, of which 40 participants were suspected of or diagnosed with AMI, while 30 healthy subjects  were included as a control group. Three ml of venous blood were collected in lithium heparin containers. Troponin I (TnI) as a cardiac biomarker was measured by TOSOH AIA-360, while the NTproBNP level was detected using I-Chroma II. Personal and clinical data were collected directly from each participant using a predesigned questionnaire.


Results: A significant increase in the TnI level (mean: 13.13 ± 18.9 ng/ml) and NTproBNP (mean: 5756.5 ± 8378.2 pg/mL) in AMI patients were detected when compared with control mean (0.02 ± 0.00 ng/ml and 57.8 ± 42.32 pg/mL, respectively).


Conclusions: NTproBNP gave a high sensitivity (87.5%), specificity (100%), positive predictive value (100%), and negative predictive value (85.7%) in the diagnosis of AMI when compared with another cardiac biomarker such as TnI.


Keywords: acute myocardial infarction, NTproBNP, troponin I, Medani Heart Center, Sudan

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