Prevalence of Transfusion Transmissible Infection among Healthy Blood Donors at Dongola Specialized Hospital, Sudan, 2010–2015

Abstract

Background: Blood transfusion saves lives but carries the risk of transmission of infections. Screening donors for transfusion transmissible infection (TTI) is mandatory.


Objectives: To study the prevalence of TTI among blood donors at Dongola Specialized hospital, Northern State, Sudan.


Materials and Methods: Retrospective study performed on blood donors at the blood bank of Dongola Specialized Hospital during the period 2010–2015. Demographic data and results of screening tests for all donors in the study period were included. Data were analyzed using SPSS and results were presented in percentages.


Results: The total number of donors were 6,489, of which 6,433 (99.1%) were included in the study. All donors were males and family donors. Mean age (SD) was 27.9 (6.516) years. hepatitis B virus was detected in 85 (1.3%), syphilis in 68 (1.1%), hepatitis virus in 45 (0.7%), and human immunodeficiency virus in 3 (0.05%) donors. Coinfections of hepatitis B with syphilis and hepatitis B with hepatitis C were found in 0.05% and 0.03% of the donors, respectively. 


Conclusion: The prevalence of TTI is low compared to national and international figures. These findings may reflect low prevalence rates of the studied infections in the community.


Key words: blood donors, Northern State, Sudan, transfusion transmissible infection

References
1- Highlights of Transfusion Medicine History file:///D:/donors/Highlights%20of%20Transfusion%20Medicine%20History.htm accessed on 27/03/2020.
2- https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability. accessed on 27/03/2020.
3- Global Status Report on Blood Safety and Availability 2016. https://apps.who.int/iris/bitstream/handle/10665/254987/9789241565431-eng.pdf;jsessionid=7F534699DBFA4B72C0C8AE36F62DD429?sequence=1 accessed on 27/03/2020.
4- Global Database on Blood Supply, Summery Report 2011. https://www.who.int/bloodsafety/global_database/GDBS_Summary_Report_2011.pdf?ua=1 accessed on 27/03/2020.
5- Mudawi HM. Epidemiology of viral hepatitis in Sudan. Clin Exp Gastroenterol. 2008; 1:9–13. doi:10.2147/ceg.s3887
6- https://www.unaids.org/en/regionscountries/countries/sudan accessed on 29/03/2020. Accessed on 27/03/2020.
7- Abdelmola AO. Prevalence and factors associated with syphilis among pregnant women attending antenatal care, Khartoum State, Sudan. Int J Advanced Med 2018; 5(2): 218-223. doi:http://dx.doi.org/10.18203/2349-3933.ijam20181062.
8- Ahmed NOA, Omer ED, Mohammed MAA. Sero-prevalence of Transfusion Transmissible Infections among Blood Donors in Khartoum Central Sudan. European Academic Research; Vol. IV, Issue 3/ June 2016: 2234-2246
9- Tajeldin M. Abdallah1, Abdel Aziem A. Ali. Sero-prevalence of transfusion-transmissible infectious diseases among blood donors in Kassala, Eastern Sudan. Journal of Medicine and Medical Science 2011; 2 (11) :pp.xxx-xxx. Available online http://www.interesjournals.org/JMMS
10- Mohammed BA, Badneen MA, Gibreel MO, Othman SA. Prevalence of transfusion-transmissible infections among blood donors in Port Sudan. Egypt J Haematol 2019; 44:72-6.
11- Elfaki AMH, Agab Eldor AA, Elsheikh NMH. Sero-prevalence of Immunodeficiency virus, Hepatitis B and C and Syphilis among Blood Donors at ElObeid Hospital, West Sudan. Sudan J Med Sc 2008;3(4): 333-337.
12- Hussein E. Blood Donor Recruitment Strategies and their Impact on Blood Safety in Egypt. Transfusion and Apheresis Science 2014; 50(1): 63-67. DOI:https://doi.org/10.1016/j.transci.2013.11.005
13- Sarah AE, Sabry AEE, Maryam AAS. Seropositivity of TTIs among Blood Donors in Hail, Saudi Arabia, from 2014 to 2015. Asian Pacific Journal of Tropical Disease 2016; 6(2): 141-146. DOI: 10.1016/S2222-1808(15)61000-3
14- Shiferaw E, Tadilo W, Melkie I, Shiferaw M (2019) Sero-prevalence and trends of transfusion-transmissible infections among blood donors at Bahir Dar district blood bank, northwest Ethiopia: A four year retrospective study. PLoS ONE 14(4): e0214755. https://doi.org/10.1371/journal.pone.0214755
15- Vermeulen M, Swanevelder R, Chowdhury D, et al. Use of Blood Donor Screening to Monitor Prevalence of HIV and Hepatitis B and C Viruses, South Africa. Emerg Infect Dis. 2017;23(9):1560–1563. doi:10.3201/eid2309.161594