High Sensitive C Reactive Protein in Sudanese Type 2 Diabetic Patients

Abstract

Background: Researchers proved the association between inflammatory condition, high sensitive C reactive protein (hs-CRP), and cardiovascular diseases (CVDs) in type 2 diabetes mellitus (DM). Therefore, this study aimed to assess the hs-CRP level in type 2 DM patients and their relation to diabetes cardiovascular complications.

Materials and methods: In a case-control study, 205 previously diagnosed type 2 DM patients and 100 controls were included. Serum high Sensitive C Reactive Protein (hs-CRP) was estimated immune-turbidimetrically using Cobas C-311® fully automated analyzer. Also, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were measured.

Results: Type 2 DM patients had an increased level of hs-CRP (p-value 0.020). Females had higher levels of hs-CRP, TC, HDL-C, and LDL-C than males (p-value 0.005, 0.000, 0.000, and 0.000, respectively). Moreover, patients who received statin drugs had decreased levels of hs-CRP, TC, and LDL-C (p-value 0.030, 0.000, and 0.000, respectively). The correlation analysis revealed hs-CRP correlates positively with BMI (r: 0.56, P-value 0.000).

Conclusion: The data showed that type 2 DM patients had higher hs-CRP. Moreover, hs-CRP positively associated with BMI. Therefore, obesity might be related to CVDs in type 2 DM patient.

Keywords

High sensitive C reactive protein, cardiovascular diseases, type 2 DM, obesity, Sudan.