Recent Update on Serum Alkaline and Acid Phosphatases in Pre- and Postoperative Breast Cancer Patients


Background: Breast carcinoma in females is an ever-growing malaise with significant mortality and morbidity. In resource-poor settings, the need for a cost-effective and reliable diagnostic tool is of utmost importance.

Methods: In the present study, 54 histopathologically proven breast cancer patients were investigated for their pre- and postoperative serum ALP and ACP levels.

Results: A total of 34 cases (belonging to the age interval of 40–60 years) exhibited a significant drop in serum ALP level after surgery (P = 0.002). Although the serum ACP also showed a postoperative decline, it was not as significant as that of serum ALP.

Conclusion: The role of serum ALP and ACP in the diagnosis, prognosis, and monitoring/surveillance of breast carcinoma cannot be underestimated particularly in third-world countries lacking in medical infrastructure or resource-poor settings.


alkaline phosphatase, acid phosphatase, breast cancer, malignancy

[1] Buchet, R., Millán, J. L., and Magne, D. (2013). Multisystemic functions of alkaline phosphatases. In Phosphatase modulators (pp. 27–51). Totowa, NJ: Humana Press.

[2] Yulia, A. and Wijesiriwardana, A. (2012). Extremely high isolated maternal alkaline phosphatase serum concentration–2 case reports and literature review. Archives of Disease in Childhood-Fetal and Neonatal Edition, vol. 97, no. 1, pp. A65–A66.

[3] Sharma, U., Pal, D., and Prasad, R. (2014). Alkaline phosphatase: an overview. Indian Journal of Clinical Biochemistry, vol. 29, no. 3, pp. 269–278.

[4] Usoro, N. I., Omabbe, M. C., Usoro, C. A., et al. (2010). Calcium, inorganic phosphates, alkaline and acid phosphatase activities in breast cancer patients in Calabar, Nigeria. African Health Sciences, vol. 10, no. 1, pp. 9–13.

[5] Singh, A. K., Pandey, A., Tewari, M., et al. (2013). Advanced stage of breast cancer hoist alkaline phosphatase activity: risk factor for females in India. 3 Biotech, vol. 3, no. 6, pp. 517–520.

[6] Pike, M. C., Spicer, D. V., Dahmoush, L., et al. (1993). Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiologic Reviews, vol. 15, no. 1, p. 17.

[7] Akram, M., Iqbal, M., Daniyal, M., et al. (2017). Awareness and current knowledge of breast cancer. Biological Research, vol. 50, no. 1, p. 33.

[8] Kpyati, A. and DS, J. M. (2016). Significance of serum total alkaline phosphatase levels in breast cancer. International Journal of Clinical and Biomedical Research, vol. 2, no. 1, pp. 13–15.

[9] Anders, C. K., Johnson, R., Litton, J., et al. (2009). Breast cancer before age 40 years. Seminars in Oncology, vol. 36, no. 3, pp. 237–249.

[10] Gabriel, C. A. and Domchek, S. M. (2010). Breast cancer in young women. Breast Cancer Research, vol. 12, no. 5, p. 212.

[11] Mehrgou, A. and Akouchekian, M. (2016). The importance of BRCA1 and BRCA2 genes mutations in breast cancer development. Medical Journal of the Islamic Republic of Iran, vol. 30, p. 369.

[12] Garg, P. (2016). Awareness that early cancer lump is painless could decrease breast cancer mortality in developing countries. World Journal of Clinical Oncology, vol. 7, no. 3, p. 321.

[13] Garg, P. K. and Prakash, G. (2015). Current definition of locally advanced breast cancer. Current Oncology, vol. 22, no. 5, pp. 409–410.

[14] Parthasarathy, V. and Rathnam, U. (2012). Nipple discharge: an early warning sign of breast cancer. International Journal of Preventive Medicine, vol. 3, no. 11, p. 810.

[15] Laviano, A., Meguid, M. M., and Rossi-Fanelli, F. (2003). Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies. The Lancet Oncology, vol. 4, no. 11, pp. 686–694.

[16] Mishra, S., Sharma, D. C., and Sharma, P. (2004). Studies of biochemical parameters in breast cancer with and without metastasis. Indian Journal of Clinical Biochemistry, vol. 19, no. 1, pp. 71–75.