Pharmacological Properties and Toxicological Investigation on Durio zibethinus Murr. Peel Extracts
Abstract
The ethanol extract of the dried fruit peels of Durio zibethinusMurr. was tested for cytotoxicity, antidiabetic, antihyperuricemia, and antihypercholesterolemia activities in experimental animals. The extract showed the potential activities of antidiabetic, antihyperuricemic, and antihypercholestrol agents. As an cytotoxicity agent, the extract was not potent against vero cells with an IC50 value of 1.864 μg/mL. Overall, Durio zibethinusMurr. fruit peels extracts had the potential to be used as an ingredient in herbal medicines for antidiabetic, antihyperuricemia and anti-hypercholesterolemia.
Keywords: herbal medicine; antidiabetic; antihyperuricemia; anti-hypercholesterolemia
References
[1] Husin NA, Sadequr R, Rohini K, Subhash JB. A review on the nutritional, medicinal, molecular and genome attributes of durian (Durio zibethinus L.), the king of fruits in Malaysia. Bioinformation (Biomedical Information). 2018;14(6):265–70.
[2] Foo KY. Transformation of durian biomass into a higlyvaluable end commodity opportunities. Biomass Bioenerg. 2011;35(7):2470-2478.
[3] Li Y et al. Bioactivities and health benefits of wild fruits. International Journal of Molecular Science. 2016;17(1258):2-27.
[4] Brewer CE. Criteria to select biochars for field studies based on biochar chemical properties. BioEnergy Research; 2011.
[5] Evary YM, Amir MN. Antioxidant and antidiabetes capacity of hexane, ethylacetate and ethanol extracts of durio zibethinus murr. Root. Pharmacognosy Journal. 2018;10(5):937–940.
[6] Kumar P, Sivashanmugam TM, Umamaheswari, Subhadradevi V, Jagannath P. Cholesterol esterase enzyme inhibitory and antioxidant activities of leaves of Camellia sinensis (L.) Kuntze. using in vitro models. Indonesian Journal of Pharmaceutical Science and Research. 2011;2(11):2923–2928.
[7] Maharani L, Fatimatuz Z. Identifikasi Faktor kimiawi kulit durian sebagai potensi sumber antikolesterol alami. Jurnal Bionature. 2017;18(1):59–62.
[8] Mayes. Harpes biochemistry. Murry RK, Granner DK, Mayes PA & Rodwell VW, eds. Mc Graw-Hill; 2000.
[9] Maury E, Ramsey, Kathryn M, Bass J. Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circulation Research. 2010.
[10] Muhtadi, Sari N, Sujono M, Tanti A, Suhendi A. Aktivitas antihiperurisemia dari ekstrak etanol kulit buah durian (durio zibethinus) dan biji buah kelengkeng (Euphorbia longan). Prosiding simposium penelitian bahan obat alami (SPBOA) XVI & muktamar XII perhipba. 2014.
[11] Kirby AJ, Schmidt RJ. The antioxidant activity of chinese herbs for eczema and of placebo herbs. International Journal Ethnopharmacol. 1997;56(2):103-108.
[12] Sanjaya A. Preparation of food colouring powder from suji leaves extract (Pleomele angsutifolia) in soxhlet extraction and maceration (online) (In Bahasa Indonesia) (http://lib.unnes.ac.id/12466).
[13] Muhtadi, Haryoto, Sujono, Tanti A, Suhendi A, Yen KH. Antioxidant and chemical constituents of some indonesian fruit peels, medicinal plants. International Journal of Phytomedicines and Related Industries. 2014;6(1):43-46.
[14] Stenvers DJ, Scheer FAJL, Schrauwen P et al. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019;15:75-89.
[15] Molyneux P. The use of the stable free radikal diphenyl picrylhydrazyl (DPPH) for estimating antioxidant activity. Journal Science of Technology. 2004;2:211-219.
[16] Sharma VK, Kumar S, Patel HJ, Hugar S. Hypoglycemic activity of ficus glomerata in alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences Review and Research. 2010;1:18-22.
[17] El-Missiry MA, El-Gindy AM. Amelioration of alloxan induced diabetes mellitus and oxidative stress in rats by oil of Eruca sativa seeds. Annals of Nutrition & Metabolism. 2004;44:97–100.
[18] Gupta A, Kumar R, Pandey AK. Antioxidant and antidiabetic activities of Terminalia bellirica fruit in alloxan induced diabetic rats. South African Journal of Botany. 2020;130:308-315.
[19] Dheer R, Bhatnagar P. A study of the antidiabetic activity of Barleria prionitis Linn. Indian Journal of Pharmacology. 2010;42(2):70-73.
[20] Dembitsky VM, Poovarodom S, Leontowicz H et al. The multiple nutrition properties of some exotic fruits: Biological activity and active metabolites. Food Research International. 2011;44(7):1671-1701.
[21] Ahmed D, Kumar V, Sharma M, Verma A. Target guided isolation, in vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia lebbeck Benth. Bark. BMC Complement Altern Med. 2014;14:1-12.
[22] Haruenkeit R, Poovarodom S, Vearasilp S et al. Antioxidant and antiproliferative activities of mon thong durian during ripening. Comparison of bioactive compounds. Food Chemistry. 2010;118(3):540-547.
[23] Murray RK, Granner, Rodwell. Biokimia harper. Jakarta: Buku Kedokteran EGC; 2006.
[24] Haidari F, Keshavars SA, Rashidi MR, Shahi MM. Orange juice and hesperetin supplementation to hyperuricemia rats alter oxidative stress marker and xanthine oxidoreductase activity. J. Clin Bioche, Nurt. 2009;45(3):285-219.
[25] Mo SF, Zhou F, Lv YZ, Hu QH, Zhang DM, Kong LD. Hypouricemia action of selected flavonoids in mice: structure activity relationships. Biol. Pharm. Bull. 2007;30(8):1551- 1556.
[26] Sukandar EY, Andrajati R, Sigit JI, Adnyana IK, Setiadi AP, Kusnandar. ISO Farmakoterapi. Jakarta: PT. ISFI Penerbitan; 2008.
[27] Gorinstein S et al. Antioxidant Properties and bioactive constituents of some rare exotic thai fruits and comparison with conventional fruits in vitro and in vivo studies. Food Research. 2011;44(7):2222–2232.
[28] Suhendi A, Muhtadi, Leonita A, Sudjono, Tanti A, Haryoto. Aktivitas Sitotoksik dari ekstrak kulit buah durian (Durio zibethinus Murr.) dan kelengkeng (Dimocarpus longan Mark.) terhadap sel vero dan HeLa. Simposium Nasional RAPI XIII. 2014.