Pharmacological Properties and Toxicological Investigation on Durio zibethinus Murr. Peel Extracts


The ethanol extract of the dried fruit peels of Durio zibethinusMurr. was tested for cytotoxicity, antidiabetic, antihyperuricemia, and antihypercholesterolemia activities in experimental animals. The extract showed the potential activities of antidiabetic, antihyperuricemic, and antihypercholestrol agents. As an cytotoxicity agent, the extract was not potent against vero cells with an IC50 value of 1.864 μg/mL. Overall, Durio zibethinusMurr. fruit peels extracts had the potential to be used as an ingredient in herbal medicines for antidiabetic, antihyperuricemia and anti-hypercholesterolemia.

Keywords: herbal medicine; antidiabetic; antihyperuricemia; anti-hypercholesterolemia

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