The Role of Varicocele Repair in Non-Obstructive Azoospermic Men: A Systematic Review
The outcomes of varicocele repair in non-obstructive azoospermic men remain the subject of controversy. Until now, small studies with small number of patients performed make it difficult to assess the efficacy of varicocele surgery in men with non-obstructive azoospermia. This review is performed to evaluate quality of the sperm among non-obstructive azoospermic men after varicocele repair.
 G. J. Matthews, E. D. Matthews, and M. Goldstein, Induction of spermatogenesis and achievement of pregnancy after microsurgical varicocelectomy in men with azoospermia and severe oligoasthenospermia, Fertility and Sterility, 70, no. 1, 71–75, (1998).
 T. Youssef, E. Abd-Elaal, G. Gaballah, S. Elhanbly, and E. Eldosoky, Varicocelectomy in men with nonobstructive azoospermia: Is it beneficial? International Journal of Surgery, 7, no. 4, 356–360, (2009).
 T. A. Abdel-Meguid, Predictors of sperm recovery and azoospermia relapse in men with nonobstructive azoospermia after varicocele repair, Journal of Urology, 187, no. 1, 222–226, (2012).
 R. Miyaoka and S. C. Esteves, A critical appraisal on the role of varicocele in male infertility, Advances in Urology, Article ID 597495, (2012).
 M. Çakan and U. Altu, Induction of spermatogenesis by inguinal varicocele repair in azoospermic men, Systems Biology in Reproductive Medicine, 50, no. 3, 145–150, (2004).
 P. N. Schlegel and J. Kaufmann, Role of varicocelectomy in men with nonobstructive azoospermia, Fertility and Sterility, 81, no. 6, 1585–1588, (2004).
 F. F. Pasqualotto, A. M. Lucon, J. Hallak, P. M. Góes, L. B. Saldanha, and S. Arap, Induction of spermatogenesis in azoospermic men after varicocele repair, Human Reproduction, 18, no. 1, 108–112, (2003).
 F. F. Pasqualotto, B. P. Sobreiro, J. Hallak, E. B. Pasqualotto, and A. M. Lucon, Induction of spermatogenesis in azoospermic men after varicocelectomy repair: An update, Fertility and Sterility, 85, no. 3, 635–639, (2006).
 E. D. Kim, B. B. Leibman, D. M. Grinblat, and L. I. Lipshultz, Varicocele repair improves semen parameters in azoospermic men with spermatogenic failure, Journal of Urology, 162, no. 3 I, 737–740, (1999).
 A. Kadiolu, A. Tefekli, S. Cayan, E. Kandirali, F. Erdemir, and S. Tellalolu, Microsurgical inguinal varicocele repair in azoospermic men, Urology, 57, no. 2, 328– 333, (2001).
 S. C. Esteves and S. Glina, Recovery of spermatogenesis after microsurgical subinguinal varicocele repair in azoospermic men based on testicular histology, International Braz J Urol, 31, no. 6, 541–548, (2005).
 J. S. Lee, H. J. Park, and J. T. Seo, What Is the Indication of Varicocelectomy in Men with Nonobstructive Azoospermia? Urology, 69, no. 2, 352–355, (2007).
 T. Ishikawa, Y. Kondo, K. Yamaguchi, Y. Sakamoto, and M. Fujisawa, Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia, BJU International, 101, no. 2, 216–218, (2008).
 M. Kiraç, N. Deniz, and H. Biri, The effect of microsurgical varicocelectomy on semen parameters in men with non-obstructive azoospermia, Current Urology, 6, no. 3, 136– 140, (2013).
 H. Aboutaleb, E. Elsheri, M. Omar, and T. Abdelbaky, Testicular biopsy histopathology as an indicator of successful restoration of spermatogenesis after varicocelectomy in non-obstructive azoospermia, World J Mens Heal, 32–43, (2014).
 M. Cocuzza, M. A. Cocuzza, F. M. P. Bragais, and A. Agarwal, The role of varicocele repair in the new era of assisted reproductive technology, Clinics, 63, no. 3, 395–404, (2008).
 J. W. Weedin, M. Khera, and L. I. Lipshultz, Varicocele Repair in Patients With Nonobstructive Azoospermia: A Meta-Analysis, Journal of Urology, 183, no. 6, 2309– 2315, (2010).
 S. Elzanaty, Varicocele repair in non-obstructive azoospermic men: Diagnostic value of testicular biopsy-A meta-analysis, Scandinavian Journal of Urology, 48, no. 6, 494– 498, (2014)