Effect of Red Cabbage Aqueous Extract on High-density Lipoprotein (Hdl) Levels of Male White Rats Induced By Atherogenic Diet
Abstract
Dyslipidemia is a lipid fraction abnormality in the form of an increase in total cholesterol, LDL, and triglyceride levels and a decrease in HDL. Red Cabbage Aqueous Extract (RCE) contains antioxidants, one of which is anthocyanins, that can increase HDL levels. This research was conducted to determine the effect of RCE on HDL levels of white male rats induced by an atherogenic diet. True experimental with post-test only control group design with 15 rats divided into the standard group (KN: regular feed), negative control group (K-: atherogenic diet), and three treatment groups (P1: atherogenic-diet with RCE doses of 6.65 mg; P2: atherogenic-diet with RCE doses of 13,3 mg; and P3: atherogenic-diet with RCE doses of 26.6 mg/100grBW) was used. The HDL measurement method used spectrophotometry. Brassica oleracea L extract had no significant effect (Kruskal-Wallis test p = 0.465) on HDL levels of white male rats. This result also happened due to the low bioavailability of anthocyanins in aqueous extract. The linear regression test results showed that the relationship’s strength was 0.031 or very weak with a linear proportional correlation, increasing the dose and increasing HD levels. Based on the results of the tests, there was no significant effect of giving Red Cabbage (Brassica oleracea) Aqueous Extract on HDL levels of white male rats (Rattus norvegicus wistar strain), which was induced by an atherogenic diet.
Keywords: anthocyanins, atherogenic diet, HDL, red cabbage aquous extract
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