Activity of Ethanol Extract of Homalomena Occulta Rhizome in Inhibiting Kidney Stone Formation in Wistar Rats
Homalomena occulta is a plant that grows in Madiun, especially Caruban. Patients can overcome kidney stone disease by boiling the H. occulta (nampu) rhizome with water. The present study aimed to evaluate the antilithiatic effect of the ethanol extract of the H. occulta rhizome in preventing nephrolithiasis in rats. Ethylene glycol was used to induce the urolithiasis in the Wistar rats. The rats were divided into six groups, namely I (normal), II (ethylene glycol induced), III (commercial drug treated, Cystone® 750 mg/kg BW), IV (H. occulta rhizome extract treated, dose 250 mg/kg BW), V (H. occulta rhizome extract treated, dose 500 mg/kg BW), and VI (H. occulta rhizome extract treated, dose 1000 mg/kg BW).
Keywords: kidney stone, ethylene glycol, calcium level, Homalomena occulta
 Abdurrosid LM, Maulana A, Hapsari N, Yunita, Ishaq P. Evaluation of stone free rate in patients with kidney stones performed by ESWL based on the location and size of stones at Harapan Family Hospital in Mataram for the 2015-2016 period. Unram Medical Journal. 2017;6(3):11–17.
 Nisar M, Mohammad RM, Arshad A, Hashmi I, Yousuf SM, Baig S. Influence of dietary intake on sleeping patterns of medical students. Cureus. 2019;11(2):e4106.
 Khan A. In vitro and in vivo models for the study of urolithiasis. Urologia. 2018;85(4):145–149.
 Dave C. Nephrolithiasis. Available from: https//emedicine.medscape.com/article, Medscape.https.
 Evan AP, Coe FL, Lingeman JE, Shao Y, Sommer AJ, Bledsoe SB. Mechanism of formation of human calcium oxalate renal stones on Randall’s plaque. Anatomical Record (Hoboken). 2007;290(10):1315–1323.
 Dalimartha S. Atlas of Indonesian medicinal plants. Jakarta, Indonesia: Puspa Swara.
 Afrianti R, Harun S. Determination of calcium levels in seawater dry fish and freshwater fish with method atomic absorption spectrophotometry. Stiffi Pioneer.