The Potential of Phyllanthus Niruri Plant Secondary Metabolites in Providing Antiviral Protection Against Sars-Cov-2: A Literature Review


Covid-19 is a disease that causes respiratory tract infections in humans. The Covid-19 pandemic has spread throughout the world. Meniran (Phyllanthus niruri) is a plant that has been empirically shown to be an antiviral. This study aimed to determine the potential of Phyllanthus niruri and its compounds as an antiviral for SARS-CoV-2 through a literature review. The data were analyzed descriptively using the NVIVO 12 Plus software. The parameters used were the hierarchy chart, cluster analysis, and world cloud. The results showed that two secondary metabolites of Phyllanthus niruri have the potential to provide antiviral protection against SARS-CoV-2, namely quercetin and rutin. Further research is needed to examine the validity of these findings through triangulation of the scientific reports and research in the laboratory.

Keywords: antivirus, Phyllanthus niruri, SARS-CoV-2

[1] A.N.T. Adjeng, R. Ruslin, L.O.M. Fitrawan, and A. Pascayantri, “Sosialisasi dan Edukasi Pemanfaatan Tanaman Berkhasiat Obat Dalam Menghadapi Masa Pandemi COVID19 di Kota Kendari.,” Jurnal Mandala Pengabdian Masyarakat. vol. 1, no. 2, pp. 62–69, 2020.

[2] Badan POM, Buku Saku Obat Tradisional Untuk Memelihara Daya Tahan Tubuh. Badan POM, Jakarta, 2020.

[3] B. Pan, S. Fang, J. Zhang, et al., “Chinese herbal compounds against SARS-CoV2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.,” Computational and Structural Biotechnology Journal. vol. 18, pp. 3518–3527, 2020.

[4] P.K. Agrawal, C. Agrawal, and G. Blunden, “Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (Mpro) Inhibitor:,” SAGE Journals. vol. 16, no. 4, pp. 1–12, 2021.