This article provides information on studies and evaluations of therapeutic efficacy of 5 % sodium bicarbonate solution in case of nodular dermatitis of cattle. Due to the market expansion of veterinary drugs, the periodization of unusual and new medicines as well as control methods of pathogens of farm livestock, having therapeutic and prophylactic effect, is under permanent control of specialists in the field of veterinary medicine. Recently the importance of finding modern means and methods of dealing with animal diseases aimed at the restoration of the body homeostasis has increased significantly in order to ensure the physiologically normal functioning of many enzymes, hormones and the whole body. There is a need for their rational use based on the study of changes in clinical and biochemical parameters occurring in the body under their influence and other factors contributing to the development of normal physiological status of the body (homeostasis). Based on the above, the present studies were based not only on etiological and pathogenetic, but also sanogenetic ideas about diseases with the aim of choosing the means that form the body’s normal physiological status (body homeostasis restoration), taking into account physiological characteristics of animals, and thereby providing the best medical and prophylactic efficacy [4]. Periodization of new drugs and methods to combat animal diseases that contribute to the restoration of body homeostasis is very important. This importantance has become even more significant since the increased sanitary and hygienic requirements for the use of veterinary drugs in animal husbandry, primarily for the treatment of dairy animals, which will serve as a guarantee for obtaining livestock products safe from the point of view of veterinary and sanitary norms and excellent sanitary quality.