Structural Organization of the Liver in the Presence of Pig Hepatosis


The structural organization of the liver in hepatosis and its clinical and morphological manifestation in pigs were studied. In animals with reduced vitality, the liver underwent deep microscopic and ultrastructural changes. At hepatic steatosis, the liver had a cellular structure, many lipid vacuoles and the damage of mitochondrial membranes of a granular endoplasmic reticulum appeared in hepatocytes. Proteinosis was characterized by impaired of lobular structure, with protein swelling of the cytoplasm of hepatocytes and Disse’s spaces expansion, significant decrease of glycogen; mitochondrial swelling and the appearance of lysosomal vacuoles in the hepatocyte. In massive hepatic necrosis, hepatocyte dystrophy was noted, significant histochemical decrease of glycogen, lysis of the hepatocyte granule endoplasmic reticulum, pycnosis of the hepatocyte nucleus, and in general necrobiotic changes in the liver cells.

[1] Baimatov, V.N., Davletov, E.G. (1998). Morphological and biochemical changes in the organism of animals and humans in hepatopathy. Moscow, 147 p.

[2] Buzlama, V.S. (1999). Ecological aspects of animal pathology. Ecological Aspects of Animal Epizootology and Animal Pathology. Conf., Dev. 100th anniversary of the birth of member-corr. VASKhNIL V.T. Kotov. Voronezh, pp. 239–240.

[3] Zharov, A.V. (2000). Patterns of structural and functional changes in metabolic pathologies in animals. Material of Conference ``Theoretical and practical aspects of the emergence and development of animal diseases and the protection of their health in modern conditions''. Voronezh, pp. 45–47.

[4] Smolentsev S.Yu. (2016). Prevention of pig hepatosis using covertal. Vestnik of Mari State University. Series Agricultural Sciences. Economic Sciences, no. 1(5), pp. 57–60.

[5] Suleymanov, S.M., Slobodianik, V.S. (2001). Structural and functional mechanisms of the occurrence and development of pathology in young farm animals (Reports of the RAAS, vol. 2, pp. 39–42).