The Therapeutic Effects of Topical Application of Ozonized Olive Oil on Diabetic Ulcer Healing: A Literature Review


Diabetic ulcers is one of diabetic complications often experienced by patients with diabetes mellitus (DM). This problem lead to serious condition which usually have an effect on patients’ quality of life. Application and research about wound care management in diabetic ulcer, specifically in ozone and olive oil, have been done already. However, exploration of how does the therapeutic effect of ozonized olive oils still limited. The purpose of this literature review is to determine the effectiveness of ozonized olive oil as topical treatment in diabetic ulcer. Source of databases in this literature review are Science direct, PubMed, and Google scholar. Articles were limited for 10 years from January 2009 to May 2019 which can be accessed full text in English.Type of literature included were review articles and research articles which the research area is in human. A qualitative analysis was performed to interpret the data. Therewere5847articlesbasedonthekeywords.Fourstudiesmettheinclusioncriteria then were analyzed. Results of this review stated that it has been recently proved that ozonized olive oils are effective to care diabetic ulcer. It is useful as antiseptic, anti-fungal, topical antibiotics, anti-infections, and continued to be healing stimulator. This review provides clinical evidence which supports and recommends the benefits of ozonized olive oil in diabetic ulcer healing.

[1] Packer, C. F., & Manna, B. (2019). Diabetic Ulcer (March 24,). Retrieved from https://www.ncbi.nlm.nih. gov/books/NBK499887/

[2] Bortoletto, M. S. S., de Andrade, S. M., Matsuo, T., Haddad, M. D. C. L., González, A. D., & Silva, A. M. R. (2014). Risk factors for foot ulcers–a cross sectional survey from a primary care setting in Brazil. Primary Care Diabetes, 8(1), 71–76.

[3] Yusuf, S., Okuwa, M., Irwan, M., Rassa, S., Laitung, B., Thalib, A., … Sugama, J. (2016). Prevalence and RiskFactorofDiabeticFootUlcersinaRegionalHospital,EasternIndonesia.Open Journal of Nursing, 6(January), 1–10.

[4] Zhang, P., Lu, J., Jing, Y., Tang, S., Zhu, D., & Bi, Y. (2017). Annals of Medicine Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. 3890. 07853890.2016.1231932

[5] Enas Mohamed Ali. (2013). Ozone Application for Preventing Fungal Infection. Diabetalogia Croatica, 42(1), 3–22.

[6] Montevecchi, M., Dorigo, A., Cricca, M., & Checchi, L. (2013). Comparison of the antibacterial activity of an ozonated oil with chlorhexidine digluconate and povidone-iodine. A disk diffusion test. New Microbiologica, 36(3), 289–302.

[7] Karateeva, S. Y., & Milkov, B. O. (2009). OZONOTHERAPY IN THE COMPLEX TREATMENT OF PURULENT – INFLAMMATORY COMPLICATIONS IN. Clin. and Experim. Pathol., 8(4), 113–116.

[8] Aziza, Nahad, Nabila, & Wael. (2011). Comparative Study of Ozonated Olive Oil Ointment versus Conventional Dressing Methods on the Healing of Grade I Diabetic Foot Ulcers. Researchers, 3(8), 16–30.

[9] Elshenawie,H.A.,Shalan,W.E.A.,&Abdelaziz,A.E.(2013).EffectofOzoneOliveOilOintmentDressing TechniqueontheHealingofSuperficialandDeepDiabeticFootUlcers. Journal of American Science, 9(11), 235–250.