The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity due to Intrauterine Varicella Infection


Aplasia cutis congenital (ACC) in lower legs is a rare disease with the absence of the skin, which commonly localized, widespread or scarred at birth. The exact pathophysiology remains unclear, and varicella infection may have essential roles in the aetiologies. Wound healing can be accelerated by using Human Dermal Papillae
Conditioned Medium (HDPCM) which has multi-lineage potential differentiation and releases many growth factors. This paper reports the possibility of using human dermal papillae conditioned media to speed up the wound healing process. A 4 days old baby boy presented with ulcers on his both knees since birth and had no history of birth trauma. The mother had varicella infection during the 2

[1] Ahan U, Janei T 2002 Br. J. Plast Surg. 55(6) 530–2.

[2] Skoufi G, Lialios G, Plachouras N, Kutsogiannis D and Mperis A 2006 Pediatr Int. 48(5) 507-9

[3] Rocha D, Rodrigues J, Marques JS, Pinto R and Gomes A 2015 Clin Case Reports 3(10):841-4

[4] Hadiuzzaman M 2013 Iran J Dermatology 16(63):36–8

[5] Browning JC 2013 Dermatol Ther 26(6) 439-44

[6] Chung KH, Kim TK, Cho BC, Jeon SW and Chung HY 2009 Dermatologic Surg. 35(3) 546–9.

[7] Gupta R, Gupta MK and Kakkar M 2014 Obstetrics and Gynecology 24(9) 854-5

[8] Utami RD, Widhiati S 2017 Aplasia kutis kongenita disebabkan infeksi intrauterin varisela: satu laporan kasus. Surakarta

[9] Karaman A, Kahveci H, Kacmaz E and Ataoglu S 2013 Goztep Tip Derg. 28(4) 220–3

[10] Leirós GJ, Kusinsky AG, Drago H, Bossi S, Sturla F, Castellanos ML, et al. 2014 Stem Cells Transl Med. 3(10) 1209-19

[11] Antaya R SJ 2012 Developmental Anomalies. In: Bolognia JL, Jorizzo JL, Schaffer JV, Callen JP, Cerroni L, Heymann WR et al editor, editor. Dermatology 3rd ed (New York: Elsevier Saunders) p. 993–1010.

[12] Tollefson MM 2012 Neo Reviews 13(5)

[13] Martinez-regueira S, Vazquez-lopez ME, Somoza-rubio C, Morales-redondo R and Gonzalez-gay MA 2006 Pediatr Dermatol 23(6) 528-32

[14] Scales BS and Huffnagle GB 2013 The Journal of Pathology 229(2)

[15] Kim HO, Choi SM and Kim HS 2013 Tissue Eng Regen Med. 10(3) 93-101

[16] Cha J, Falanga V 2007 Clin Dermatol 25(1) 73–8.

[17] Zou J-P, Huang S, Peng Y, Liu H-W, Cheng B, Fu X-B, et al. 2012 Int. J. Low Extrem Wounds. 11(4) 244–53

[18] Weissman IL 2000 Cell 100(1)157–68.

[19] Driskell RR, Clavel C, Rendl M and Watt FM 2011 J Cell Sci 124(8)1179–82.

[20] Fujie T, Katoh S, Oura H, Urano Y and Arase S 2001 J Dermatol Sci. 25(3) 206–12.