The Effects of Allopurinol on Glutathione Sulfhydryl (GSH) Serum Level, %FEV1, Six Minute Walking Test, and CAT Score of Chronis Obstructive Pulmonary Disease Patients


Introduction: Stress oxidative in chronic obstructive pulmonary disease (COPD) impaired striated muscle thus worsening COPD clinical symptoms. Allopurinol as antioxidant reduces stress oxidative in COPD so it can improve exercise capacity and clinical symptoms of COPD patients. The aims of this study were to analyze the effect of allopurinol on glutathione sulfhydryl (GSH) serum level, %FEV1 , six-minute walking test (6MWT), and COPD assessment test (CAT) score of COPD group C and D patients.

Methods: This was a pre and post test group clinical trials held in pulmonology outpatient clinic in Dr. Moewardi general hospital, Surakarta from January to February 2018 using purposive sampling. The COPD group C and D patients were categorized as intervention group which received allopurinol 300 mg/day for four weeks and a control group which did not receive allopurinol. Glutathione sulfhydryl serum level, %FEV1, 6MWT, and CAT score were measured at baseline and after four weeks in both groups.

Results: A total of 37 stable COPD group C and D patients were included in this study. The intervention group showed decreased of GSH level (52.58 ± 38.39) µg/ml and CAT score (10.37 ± 4.46) which were statistically significant compared to control group (p<0,05) while decreased of %FEV1 in intervention group (6.91 ± 10.60) and control group (8.43 ± 11.26) were not significant statistically (p=0.94). The intervention group also showed a significant increase of 6MWT (p=0.005) while the control group showed no significant increase (p=0.109); however, the 6MWT differences in both groups were not significant with p=0.057.

Conclusion: Allopurinol decreased GSH serum level, did not influence %FEV1 , increased 6MWT, and decreased CAT score of stable COPD group C and D patients.

Keywords: COPD, allopurinol, GSH, %FEV1, 6MWT, CAT

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