The Serological Findings of Parvo virus B19 and Neopterin Detection among Sickle cell Disease Patients and Blood Doners in the Kingdom of Bahrain
Abstract
Introduction. Parvovirus B19 (PV B19) is a small, non-enveloped, ss DNA virus with an icosahedral capsid having a size of 18–26 nm. PV B19 transmits through respiratory droplets, blood transfusion and nosocomial infections that have also been documented recently. The virus targets the actively dividing Erythroid Progenitor Cells (EPCs) that are found in the human bone marrow, fetal liver and human umbilical cord. Methods. The study was particularly conducted on Sickle Cell Disease (SCD) patients and focuses on the determination of parvovirus B19 among Bahraini population by relying on their clinical status. The serological study of PV B19 was performed using Enzyme Linked Immunosorbent Assay (ELISA) technique and includes 150 SCD patients
and 100 healthy blood donors in which both males and females were employed. The samples were taken from the emergency unit of Salmania Medical Complex (SMC) and Ibrahim Khalil Kano Center (IKKC). Results. Of the 150 SCD patients, 100 were with vaso-occlusive crisis(VOC) and 50 non-vaso-occlusive crisis (NVOC). The three groups showed significantly higher percentages of PV B19 IgG but the percentage in SCD was relatively high compared to the control group of age-matched healthy donors – 70% of the VOC patients, 76% of the NVOC cases and 57% of blood donors were found to be IgG sero-positive. Discussion and Conclusion. PV B19 is a pathogenic virus and sometimes considered as life-threatening specifically for those individuals who have SCD due to which a risk of transient aplastic crisis increases. This virus is only associated with those patients who
have some hematological disorders such as hemolytic anemia and erythro-cytopenia. An effective screening test must be performed in the future to reduce the risk of PV B19 infection.
Keywords: Aplastic Crisis, Seroprevalence, Bahraini Population, Genotypes, Vasoocclusive crisis, Neopterin
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