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Putri, R. F., Chitivema, E., Marwoto, M., & Prasetyo, A. A. (2015). MACROPHAGE INFLAMMATORY PROTEIN 2-Alpha (MIP-2) IN HIV PATIENTS LEADING TO LUNG INJURY AFTER <i>Pneumocystis jiroveci</i&gt; INFECTION. KnE Life Sciences, 2(1), 58-63. https://doi.org/10.18502/kls.v2i1.117

https://doi.org/10.18502/kls.v2i1.117

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authors

  • Rizqa Febriliany Putri

    Rizqa Febriliany Putri

    Biomedical Laboratory Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta
  • Egtheastraqita Chitivema

    Egtheastraqita Chitivema

    Biomedical Laboratory Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta,
  • Marwoto Marwoto

    Marwoto Marwoto

    Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta
  • Afiono Agung Prasetyo

    Afiono Agung Prasetyo

    Biomedical Laboratory Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta Center of Biotechnology and Biodiversity Research and Development, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta

Published Date

  • Sep 20, 2015

MACROPHAGE INFLAMMATORY PROTEIN 2-Alpha (MIP-2) IN HIV PATIENTS LEADING TO LUNG INJURY AFTER <i>Pneumocystis jiroveci</i> INFECTION

KnE Life Sciences / International Conference on Biological Sciences (ICBS-2013) / Pages 58-63

Abstract

Introduction: Exuberant inflammation during Pneumonia caused by Pneumocystis jiroveci strongly promotes pulmonary injury in HIV patients and suggested caused by Macrophage Inflammatory Protein 2- Alpha (MIP-2) as a strong chemoattractant.Aims: To understanding the potential roles of MIP-2 in the pulmonary injury in HIV patients.Methods: All complete coding sequences of human MIP-2 deposited inGenBank were downloadedand subjected for bioinformatics analysis.Results: Human MIP-2 lacks the highly conserved purine at position -3 but possess many features of the consensus sequence. The consensus polyadenylation signal was present in the hu-MIP-2a cDNA at position 1182-1187of the 3' untranslated region followed by a poly(A) beginning at nucleotide 1202. The cysteine alignment and the presence of non conserved amino acid were defining the properties of chemokines in case of what substances that could be attracted. The mechanism of lung injury perhaps does not caused by alteration of MIP-2 directly.

Keywords: MIP-2, HIV, lung injury, Pneumocystis jiroveci 

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