Inhibition of Apoptosis in Retinal of Newborn Mice Due to Congenital Toxoplasmosis
Abstract
Toxoplasma gondii infection in pregnant women cause defects in the newborn, such as hydrocephalus and eye damaged, even blindness. Histologically damage due to congenital infection of T. gondii need to be examined. Twenty pregnant mice were divided into two groups which are the treatment group and the control group. Each mouse in treatment group was infected with 10 takizoit by intraperitoneal. Each of the newborn were sacrified, their head were taken and their eye tissue were fixed in 10% of buffered formalin and the histological sample were made in HE and TUNEL staining. The result showed that the retina of the eye of the newborn from infected mice damage. The damages include: hemorrhage, infected retinal cells, eye growth inhibition and decreased of apoptosis index of the retina cells.
Keywords: Apoptosis in retinal, Newborn, Congenital Toxoplasmosis,
Ocular Toxoplasmosis
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