Performance Evaluation of Active and Non-active Electrodes for Doxorubicin Electro-oxidation
Electrochemical remediation is an innovative technique that utilizes electro-oxidation reactions to degrade micropollutants such as doxorubicin (DOX) that is a drug widely used to treat many types of cancer, and it is present in hospital effluents. The aim of this work is to evaluate the efficiency of active and non-active electrodes in DOX degradation during electrochemical treatments. AuO-TiO2@graphite, a nanostructured electrode, and BDD, a commercial electrode, were used as active and non-active electrodes respectively. DOX treatments were realized at concentration of 1.25 mmol L-1 in medium with 10 mmol L-1 NaCl as support electrolyte. Studies were realized in 5 V of voltage source. Results: The treatment of DOX with BDD promoted 100% of DOX degradation in 20 min, while the same result was obtained for the AuO-TiO2@graphite in 40 min of treatment. Also, the modified electrode presented an energy expenditure of 1.12 kWh m-3 and the BDD achieved 0.462 kWh m-3. Thus, the active and non-active electrodes were efficient to promote DOX degradation, and the BDD, the non-active electrode demonstrated a better performance.
Keywords: Eletro-Oxidadion, Modified Graphite Anodes, BDD, Doxorubicin, Micropollutants
 Sirés, I. and Brillas, E. (2012). Remediation of water pollution caused by pharmaceutical residues based on electrochemical separation and degradation technologies: A review. Environ Internat, vol. 40, pp. 212–229.
 Panizza, M. and Martinez-Huitle, C.A. (2013). Role of electrode materials for the anodic oxidation of a real landfill leachate – Comparison between Ti–Ru–Sn ternary oxide, PbO2 and boron-doped diamond anode. Chemosphere, vol 90, issue 4, pp. 1455–1460.
 Moreira, F.C., Boaventura, R.A.R., Brillas, E. et al. (2017). Applied Catalysis B Environmental Electrochemical advanced oxidation processes A review on their application to synthetic and real wastewaters. Applied Catalysis B, Environmental, vol. 202, pp. 217–261.
 Panizza, M.E. and Cerisola, G. (2009). Direct and mediated anodic oxidation of organic pollutants”. Chemical Reviews, vol. 109, pp. 6541–69.
 Palchik, V., Traverso, M. L., Colautti, M. et al. (2016). Oncology medications prescription in a cancer service: appropriateness to clinical practice guidelines. Farmacia Hospitalaria, vol 40, issue 6, pp. 491-495.
 Mahnik, S.N.; Lenz, K.; Weissenbacher, N., et al (2007). Fate of 5- fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimi- nation by activated sludge and treatment in a membrane-bio-reactor system. Chemosphere, vol. 66, pp. 30–7.
 Marselli, B., Garcia-Gomez, J., Michaud, P. A., et al (2003). Electrogeneration of hydroxyl radicals on boron-doped diamond electrodes”. Journal of the Electrochemical Society, vol 150, issue 3, pp. 150, 79–83.
 Farinos, R.M. and Ruotolo, L.A.M. (2017). Comparison of the electrooxidation performance of threedimensional RVC/PbO2 and boron-doped diamond electrodes. Electrochimica Acta, vol. 224, pp. 32–39.
 Ganiyu, S.O., Oturan, N., Raffy, S., et al (2016). Sub-stoichiometric titanium oxide (Ti4O7) as a suitable ceramic anode for electrooxidation of organic pollutants: A case study of kinetics, mineralization and toxicity assessment of amoxicillin. Water Research, vol 1, issue 6, pp.171-172.
 Montilla, F., Morallo, E., De Battisti, A. et al (2004). Preparation and characterization of antimony-doped tin dioxide electrodes. Part 2. XRD and EXAFS characterization. Journal of Physical Chemistry B, vol. 108, pp. 5044-5050.
 Cherevkoa, S., Geiger, S., Kasiana, O., et al (2015). Oxygen and hydrogen evolution reactions on Ru, RuO2, Ir, and IrO2 thin film electrodes in acidic and alkaline electrolytes: A comparative study on activity and stability. Catalysis Today, vol. 262, pp. 170-180.
 Särkkä, H., Vepsäläinen, M. and Sillanpää, M. (2015). Natural organic matter (NOM) removal by electro- chemical methods – A review. Journal of electroanalytical chemistry, vol. 755, pp. 100–108.
 Dunnill, C.W., Kafizas, A., and Parkin, I.P. (2012). CVD Production of Doped Titanium Dioxide Thin Films”. Chemical Vapor Deposition, vol. 18, pp. 89-101.
 Moreno, E.K.G., Garcia, L.F., Lobón, G.S. et al (2019). Ecotoxicological assessment and electrochemical remediation of doxorubicin”. Ecotoxicology and Environmental Safety, vol. 179, pp. 143–150.
 Sanz-Lobón, G., Yepez, A., Garcia, L.F., et al (2017). Efficient electrochemical remediation of microcystin- LR in tap water using de- signer TiO2@carbon electrodes. Sci Rep Vol. 7, pp. 41326.
 Garcia, L.F., Moreno, E.K.G., Brito, L.B., et al. Electro-chemical doxorubicin removal on boron doped diamond: and effective technology to abate ecotoxicity. (In preparation).
 Mohora, E., Roncevic, S., Dalmacija, B., et al (2012). Removal of natural organic matter and arsenic from water by electrocoagulation/flotation continuous flow reactor. J. Hazard. Mater, vol. 235–236, pp. 257–264.
 Salazar, C., Contreras, N., Mansilla, H.D., et al (2016). Electrochemical degradation of the antihypertensive losartan in aqueous medium by electro-oxidation with boron-doped diamond electrode. J Hazard Mater, vol. 319, pp. 84-92.
 Kadu, B.S., Wani, K.D., Kaul-Ghanekar, R., et al (2017). Degradation of doxorubicin to non-toxic metabolites using Fe-Ni bimetallic nanoparticles. Chem Eng J, vol. 325, pp. 715–724.
 Ganzenko, O., Oturan, N., Sirés, I. et al. (2018). Fast and complete removal of the 5-fluorouracil drug from water by electro-Fenton oxidation. Environmental Chemistry Letters, vol. 16, issue 1, pp. 1–6.
 Fabiańska, A., Ofiarska, A., Fiszka-Borzyszkowska, A. et al. (2015). Electrodegradation of ifosfamide and cyclophosphamide at BDD electrode: Decomposition pathway and its kinetics. Chemical Engineering Journal, vol. 276, pp. 274–282.
 Siedlecka, E.M., Ofiarska, A., Borzyszkowska, A.F., et al (2018). Cytostatic drug removal using electrochemical oxidation with BDD electrode: Degradation pathway and toxicity. Water Research, vol. 144, pp. 235- 245.