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Wiest, J. (2016). Methods and applications of label-free cell-based systems. KnE Engineering, 1(1). https://doi.org/10.18502/keg.v1i1.493

https://doi.org/10.18502/keg.v1i1.493

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  • Joachim Wiest
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Published Date

  • Sep 5, 2016

Methods and applications of label-free cell-based systems

KnE Engineering / Conference on Science and Engineering for Instrumentation, Environment and Renewable Energy /

Abstract

Label-free monitoring of living cells is used in various applications such as drug development, toxicology, regenerative medicine or environmental monitoring. The most prominent methods for monitoring the extracellular acidification, oxygen consumption, electrophysiological activity and morphological changes of living cells are described. Furthermore, the intelligent mobile lab (IMOLA) – a computer controlled system integrating cell monitoring and automated cell cultivation – is described as an example of a cell-based system for microphysiometry. Results from experiments in the field of environmental monitoring using algae are presented. An outlook toward the development of an organ-on-chip technology is given.

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