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Lipey, N. A., Linkov, K. G., Yakovlev, D. V., Volkov, V. V., & Loschenov, V. B. (2018). Fiber Optic Devices for Endobiliary Photodynamic Therapy. KnE Engineering, 3(6), 196–201. https://doi.org/10.18502/keg.v3i6.2992

https://doi.org/10.18502/keg.v3i6.2992

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authors

  • N A Lipey
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  • K G Linkov
    No author data available.
  • D V Yakovlev
    No author data available.
  • V V Volkov
    No author data available.
  • V B Loschenov
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Published Date

  • Oct 8, 2018

Fiber Optic Devices for Endobiliary Photodynamic Therapy

KnE Engineering / Breakthrough directions of scientific research at MEPhI: Development prospects within the Strategic Academic Units / Pages 196–201

Abstract

The aim of the study is to optimize the irradiation procedure during endobiliary photodynamic therapy for patients with cholangiocarcinoma. The studies were performed using fiber-optic light delivery tools in various configurations and using different irradiation power levels. Control of photosensitizer accumulation at the site of therapy was also applied. It is shown that the use of fiber-optic light delivery tools with cylindrical diffusers provides more effective and less painful photodynamic therapy. It is shown that after the injection of the photosensitizer, there is an optimal time for the therapy, when the maximum difference in the accumulation of the photosensitizer in the tumor is observed in comparison with the intact tissue.


 


 


Keywords: endobiliary photodynamic therapy, fluorescent diagnostics, fiber-optic light delivery tools, cholangiocarcinoma

References
[1] Dolgushin, B. I., Sergeeva, O. N., Frantsev, D. Y., et al. (2016). Intraductal photodynamic therapy of portal cholangiocarcinoma for inoperable patients. Annals of Surgical Hepatology, vol. 21, no. 3, pp. 106–118 (in Russian).


[2] Shiryaev, A. A., Musaev, G. K., Loshchenov, M. V., et al. (2017). Combined minimally invasive treatment of cholangiocellular cancer complicated by obstructive jaundice. Intraductal Videofluorescent Diagnostics - The First Experience in Russia. Annals of Surgical Hepatology, vol. 22, no. 1, pp. 71–81 (in Russian).


[3] Shiryaev, A. A., Musaev, G. Kh., Loshchenov, M. V., et al. (2016). Fluorescence diagnosis and photodynamic therapy in combined treatment of cholangiocarcinoma. Biomedical Photonics, vol. 5, no. 4, pp. 15–24 (in Russian).


[4] Levkin, V. V., Kharnas, S. S., Zavonov, V. Y., et al. (2015). Laser spectral and video fluorescence diagnostics of stomach diseases with 5-aminolevulinic acid hydrochloride (preparation Alasens). Bulletin of Surgical Gastroenterology, no. 1–2, pp. 13–20 (in Russian).


[5] Grachev, P. V., Volkov, V. V., Linkov, K. G., et al. (2013). Precision delivery systems and laser methods of control during PD and PDT. Photodynamic Therapy and Photodiagnosis, no. 3, pp. 42–43 (in Russian).


[6] Lipey, N. A., Yakovlev, D. V., Grachev, P. V., et al. (2017). Fiber optic devices for endobiliary photodynamic therapy. 16th World Congress IPA, p. 235.


[7] Loschenov, V. B., Linkov, K. G., Savelieva, T. A., et al. (2013). Hardware and tool equipment for fluorescence diagnostics and photodynamic therapy. Photodynamic Therapy and Photodiagnosis, vol. 2, no. 3, pp. 17–25 (in Russian).


[8] Linkov, K. G., Berezin, A. N., and Loschenov, V. B. (2005). The equipment for fluorescent diagnostics and photodynamic therapy. Russian Biotherapeutic Journal, vol. 4, no. 4, pp. 114–119 (in Russian).