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N.V., N., E.E., B., E.V., I., E.P., M., O.Y., G., L.N., U., A.E., C., V.O., S., O.G., L., & S.Е.U. (2018). RBE of "Prometeus" Facility Protons for Irradiation of Tumor Cells in vitro with One and Three Fields. KnE Engineering, 3(3), 309-316. https://doi.org/10.18502/keg.v3i3.1630

https://doi.org/10.18502/keg.v3i3.1630

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authors

  • Nasedkina N.V.
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  • Beketov E.E.
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  • Isaeva E.V.
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  • Malakhov E.P.
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  • Golovanova O.Y.
    No author data available.
  • Ulyanenko L.N.
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  • Chernukha A.E.
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  • Saburov V.O.
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  • Lepilina O.G.
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  • Ulyanenko S.Е.
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Published Date

  • Feb 21, 2018

RBE of "Prometeus" Facility Protons for Irradiation of Tumor Cells in vitro with One and Three Fields

KnE Engineering / XIII International Youth Scientific and Practical Conference "FUTURE OF ATOMIC ENERGY - AtomFuture 2017" / Pages 309-316

Abstract

The study was aimed to the biological effectiveness of the proton scanning beam of the first Russian medical facility. The clonogenic assay of B-16 tumor cells was used as a test system. Cell irradiation was carried out in a suspension condition in a water phantom. Single and three-field exposures were studied. The dose interval was 2-8 Gy. The energy range from 47.5 to 92.0 MeV was used for the Bragg peak formation. The relative biological effectiveness of protons comparing to gamma-rays was 1.2 for single-field and 1.5 for three-field irradiation. The results obtained agree with literature data related to the used cell culture (B-16) and linear energy transfer range (3÷8 keV/µm).

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